cis-4-tert-butylcyclohexyl acetate

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 2013-02-22 to 2013-03-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Substance ID is adequately specified with purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP Compliance Programme (inspected on 10 July 2012 / signed on 30 Nov. 2012)

Type of method:

gas saturation method

Specific details on test material used for the study:

Storage condition of test material: room temperature in the dark.

Key result

Temp.:

25 °C

Vapour pressure:

7.9 Pa

Remarks on result:

other: interpolated

Average of vapor pressure (mean of three determinations (three flow rates)):

1.95 Pa at 10°C

4.99 Pa at 20°C

12.3 Pa at 30°C

The vapor pressure curve is provided in the experimental report.

The regression parameters were calculated:

ln VP (mean in Pa) = -7904.46 / T (in K) + 28.58 (r² = 1.000)

Validation

The linearity of the detector response with respect to concentration was assessed over the concentration range of 9.70 to 485 mg/L (n=5). This was satisfactory with a correlation coefficient of 1.000 being obtained.

Concentrations of sample solutions from traps 1 range between 18 and 208 mg/L, therefore within the calibration range. For traps 2 (0.17 – 0.53 mg/L), inaccuracy is considered negligible as this collected fraction represents less than 2% of the total amount.

Discussion

To ensure saturation control, three different flow rates were used at each temperature. From the data, it can be clearly seen that higher flow rates did not lead to lower vapor pressures, which means that the nitrogen was saturated with test item under the conditions of the test.

Conclusions:

Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).

Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method.

Determinations were conducted at 10, 20 and 30°C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapor pressure at 25°C was interpolated from the regression.

The vapour pressure of the test material has been determined to be 7.9 Pa at 25°C.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:

7.9 Pa

at the temperature of:

25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. The result is retained as key data for purpose of CSA.