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EC number: 402-810-3 | CAS number: 17980-47-1 DYNASILAN BH N; DYNASILAN BSM 100 N; DYNASILAN NH 42
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no in vivo data on the toxicokinetics of triethoxyisobutylsilane. The following summary has therefore been prepared based on validated predictions of the physicochemical properties of the substance itself and its hydrolysis products. Triethoxyisobutylsilane is a moisture-sensitive liquid that hydrolyses at a moderate rate in contact with water (half-life 22 hours at pH 7; predicted), generating ethanol and isobutylsilanetriol. Human exposure can occur via the inhalation or dermal routes. Relevant inhalation exposure would be to the parent and hydrolysis products.
Absorption
Oral: Significant oral exposure is not expected for this substance.
Dermal: The molecular weights of the parent and hydrolysis products do not negate the possibility of absorption across the skin, although they are not ideal. The measured water solubility (212 mg/l) and predicted log Kow (3.6) of the parent suggest that absorption across the skin is likely to be moderate to high. The predicted water solubility (miscible in all proportions) and predicted log Kow (-1.0) of the hydrolysis product, isobutylsilanetriol, are not favourable for absorption across the skin, as the substance is likely to be too hydrophilic to cross the lipid rich environment of the stratum corneum.
Inhalation: The predicted log Kow of the parent substance is favourable for absorption from the respiratory tract epithelium by passive diffusion. The very high water solubility of the hydrolysis product, isobutylsilanetriol is likely to lead to some of this hydrolysis product being retained in the mucus of the lungs. Therefore, once hydrolysis has occurred, absorption is likely to slow down. No measured data on hydrolysis kinetics in vivo are available. A 90-day repeated dose inhalation study did not provide convincing evidence for systemic availability.
Distribution
Due to the moderate rate of hydrolysis of triethoxyisobutylsilane, and lower absorption of the hydrolysis product, most of the absorbed substance is likely to be in the form of the parent, triethoxyisobutylsilane. Hydrolysis will continue to occur once the substance is in the blood. The lipophilic parent substance is likely to distribute into cells and the intracellular concentration might be higher than the extracellular concentration, particularly in fatty tissues. The hydrolysis product is not likely to distribute into cells due to its very high water solubility and low log Kow.
Metabolism
There are no data regarding the metabolism of triethoxyisobutylsilane. Genetic toxicity tests in vitro showed no observable differences in effects with and without metabolic activation for triethoxyisobutylsilane.
The hydrolysis product ethanol is rapidly metabolised via well-described pathways. Metabolism of ethanol is described extensively in the open literature and it is outside the scope of the CSR to consider this in detail.
Excretion
The low molecular weight and water solubility of the parent and hydrolysis product suggest that they are likely to be effectively eliminated via the kidneys in urine.
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