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EC number: 700-308-1 | CAS number: 1335203-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to or similar to guideline study OECD 415/GLP: data available in public domain, not all raw data included in publication.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- HPV Lubricating Oil Basestocks Test Plan and Robust Summary
- Author:
- Petroleum HPV test group
- Year:
- 2 002
- Reference Type:
- publication
- Title:
- Assessment of the potential reproductive and subchronic toxicity of EDS coal liquids in Sprague-Dawley rats.
- Author:
- Mckee, RH
- Year:
- 1 987
- Bibliographic source:
- In Toxicology, vol. 46 pp 267-280
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 415 [One-Generation Reproduction Toxicity Study (before 9 October 2017)]
- GLP compliance:
- yes
Test material
- Reference substance name:
- White mineral oil (petroleum)
- EC Number:
- 232-455-8
- EC Name:
- White mineral oil (petroleum)
- Cas Number:
- 8042-47-5
- IUPAC Name:
- 8042-47-5
- Reference substance name:
- a food/ drug grade severely refined base oil, referred to in the publication as 8012-95-1, however this is a generic reference used at the time to specify what is now referred to as 8042-47-5.
- IUPAC Name:
- a food/ drug grade severely refined base oil, referred to in the publication as 8012-95-1, however this is a generic reference used at the time to specify what is now referred to as 8042-47-5.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: white oil
- Details on exposure:
- 72 male/female Sprague-Dawley rats were given white oil at a dose of 5ml/kg, 5 days/week for 13 weeks. After this time each of the males was housed with 2 females for 10 consecutive nights, or until mating was confirmed by copulatory plug. The mated females were maintained without further dosing through gestation and lactation to post-partum day 21.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
5ml/kg
Basis:
nominal conc.
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- > 4 350 mg/kg bw/day
- Sex:
- male/female
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- no effects observed
- Mortality / viability:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Sexual maturation:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings:
- no effects observed
Details on results (F1)
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- > 4 350 mg/kg bw/day
- Sex:
- male/female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- White mineral oil (petroleum) is not a reproductive toxicant.
- Executive summary:
A one generation reproductive toxicity study was performed in Sprague Dawley rats to determine the effects of two EDS coal liquids. In this study, a white mineral oil (petroleum) was used as a vehicle control group for each test material in the study. Only the results of the white mineral oil control groups (one for each of the test materials) are summarized here.
Each of the two separate vehicle control groups contained male and female Sprague-Dawley rats. The dosed animals were given a single daily dose of 5 ml/kg (bw) of the white mineral oil. Dosing was done via gavage, 5 days/week for 13 weeks. After 13 weeks of dosing, the animals were mated. The mated females were maintained without further dosing through gestation and lactation to post-partum day 21. Gross observations of pups and dams were generally unremarkable. No treatment-related effects on the reproduction of parental rats or in the growth of F1 offspring were observed. The NOEL for both the parental and F1 offspring was determined to be >5ml/kg (approximately >4350 mg/kg/bw/day). Substance identity details supporting the use of 1white mineral oil (CAS No. 8042-47-5) as read-across can be found in ‘Section 13-Assessment Reports’ of the IUCLID dossier.
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