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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Several acute oral studies and a dermal toxicity study are available for 1,4-dihydroxyanthraquinone. No study is available for acute inhalation toxicity. This does not need to be conducted according REACH Annex VII column 2 because valid studies for acute oral and dermal toxicity are on hand.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
One group of 10 male Wister rats (average weight 160-180 g) received per gavage a single dose of 5000 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male
Route of administration:
oral: gavage
Vehicle:
other: lutrol
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
None of the animals died and no signs of intoxication were observed.
Clinical signs:
other: None of the animals died and no signs of intoxication were observed.
Gross pathology:
No data.
Other findings:
No data.

None of the animals died and no signs of intoxication were observed.

Interpretation of results:
GHS criteria not met
Conclusions:
None of the animals died and no signs of intoxication were observed. LD50 > 5000 mg/kg bw (rat, male). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

One group of 10 male Wister rats (average weight 160-180 g) received per gavage a single dose of 5000 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14. None of the animals died and no signs of intoxication were observed. LD50 > 5000 mg/kg bw (rat, male).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
5 000 mg/kg bw
Quality of whole database:
The materials/methods and results are described in detail and are sufficient for evaluation.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14.
GLP compliance:
not specified
Test type:
standard acute method
Species:
rat
Strain:
Wistar
Sex:
male
Type of coverage:
semiocclusive
Vehicle:
other: 50% lutrol
Duration of exposure:
24 hours
Doses:
2500 mg/kg bw
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
None of the animals died and no signs of intoxication were observed.
Clinical signs:
other: None of the animals died and no signs of intoxication were observed.
Gross pathology:
No data.
Other findings:
No data.

None of the animals died and no signs of intoxication were observed.

Interpretation of results:
GHS criteria not met
Conclusions:
None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14. None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 500 mg/kg bw
Quality of whole database:
The materials/methods and results are described in detail and are sufficient for evaluation.

Additional information

In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.


Justification for classification or non-classification

In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.

According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.