Registration Dossier
Registration Dossier
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EC number: 250-439-9 | CAS number: 31027-31-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: cited in BG 249 (Hoechst study)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- p-isopropylphenyl isocyanate
- EC Number:
- 250-439-9
- EC Name:
- p-isopropylphenyl isocyanate
- Cas Number:
- 31027-31-3
- Molecular formula:
- C10H11NO
- IUPAC Name:
- 1-isocyanato-4-(propan-2-yl)benzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 14 days
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- other: erythema and edema score
- Basis:
- mean
- Time point:
- other: 30 to 60 min, 24, 48 and 72 h, 7 and 14 days
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritant / corrosive response data:
- animals showed beginning 1 hour after application severe erythema and edema. reddening was observed in a greater area than the application area. the skin was deeply fissured. crustification, eschar building and erythemas were not fully reversible. substance was classified as corrosive by the authors
Any other information on results incl. tables
The animals showed one hour following application pronounced to severe erythma and severe oedema. The treated skin was up to 72 hours small area brownish and large area whitish discoloured. Until the post-observation period the skin was roughed. Crustification, eschar formation and erythema were not fully reversibel.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Executive summary:
method: skin irritation study according OECD 405
result: substance was classified as corrosive
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