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EC number: 242-217-5 | CAS number: 18328-90-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 1986 to February 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data presented as a summary report to TSCA under the Section 8 (e) Compliance Audit Programme for Reportable Adverse Effects. A full study report is not available for evaluation of the overall study reliability but the data summary presented to TSCA is adequate to determine the acute endpoint.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Three group dermal toxicity study similar to the OECD 402 test guidelines.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N-ethyl methyl allylamine
- IUPAC Name:
- N-ethyl methyl allylamine
- Reference substance name:
- N-ethylmethacrylamine
- EC Number:
- 242-217-5
- EC Name:
- N-ethylmethacrylamine
- Cas Number:
- 18328-90-0
- Molecular formula:
- C6H13N
- IUPAC Name:
- N-ethyl-2-methylprop-2-en-1-amine
- Test material form:
- other: clear yellowish liquid
- Details on test material:
- - Name of test material (as cited in study report): C-1033 (N ethyl methyl allylamine)
- Physical state: clear yellowish liquid
- Analytical purity: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Storage condition of test material: 60-85°F (circa 16-30°C)
- Other: Specific Gravity stated as 0.78 g/mL
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No information
- Weight at study initiation: No data
- Fasting period before study: No data
- Housing: No information
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: animals received on 23 September or 2 December 1986 or 5 January 1987 and dosed on 9 October or 29 December or 2 February 1987 respectively
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Room monitored over temperature range of circa 16-30°C
- Humidity (%): No information
- Air changes (per hr): No information
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: 9 October 1986 To: 9 February 1987
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No information provided for duration of exposure, preparation of dose sites or any dressing used to occlude the treatment
MAXIMUM DOSE VOLUME APPLIED:6.4 mL C-1033 was administered undiluted as 0.26 ; 2.6 and 6.4 ml to achieve dose levels of 200, 2000 or 5000 mg/kg assuming a Specific Gravity value of 0.78 g/ml - Duration of exposure:
- No information
- Doses:
- 200, 2000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- Four
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, record of mortalities - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- not specified
- Dose descriptor:
- approximate LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No rabbits died folowing dermal application of 200 mg/kg bw; 3/4 died at a dose of 2000 mg/kg bw and all four died at 5000 mg/kg bw
- Mortality:
- None of the four rabbits dosed at 200 mg/kg bw died following dermal application of C-1033. Three mortalities occurred in the 2000 mg/kg bw group and all four rabbits died after dosing at 5000 mg/kg bw.
- Clinical signs:
- other: No signs observed in the high dose group rabbits that died within 24 hours of dose application. No details are reported for effects in rabbits dosed at 2000 or 200 mg/kg bw other than stating severe dermal response were observed.
- Gross pathology:
- No data
- Other findings:
- No information
Any other information on results incl. tables
No information
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The aucte dermal LD50 was found to be greater than 200 mg/kg bw and less than 2000 mg/kg bw.
- Executive summary:
N-ethylmethlyallylamine was administered topically to groups of four rabbits at dose levels of 200, 2000 or 5000 mg/kg bw. All rabbits died in the high dose group and three of four died at 2000 mg/kg bw. Severe, unspecified, dermal responses were recorded in the two lower dose groups. No mortality occurred following application of 200 mg/kg bw. The aucte dermal LD50 was found to be greater than 200 mg/kg bw and less than 2000 mg/kg bw.
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