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EC number: 240-827-6 | CAS number: 16774-21-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27 April 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Diammonium hexanitratocerate
- EC Number:
- 240-827-6
- EC Name:
- Diammonium hexanitratocerate
- Cas Number:
- 16774-21-3
- Molecular formula:
- CeN6O18.2H4N
- IUPAC Name:
- diammonium cerium(IV) nitrate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Name of test material (as cited in study report): cerium nitrate ceriammonique 99.5
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: several accredited breeders supply animals to the Hazleton laboratories: Charles River, E.G.A.V. and Elevage Scientifique des Dombes
- Age at study initiation: no data
- Weight at study initiation: 2.5 kg ± 200 g
- Housing: individual polystyrene cages, measuring 540 x 360 x 315 mm with a perforated polystyrene floor in a ventilated and air conditioned room.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 8 days to allow time for acclimatization
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 3 °C throughout the year
- Humidity (%): 30 - 70%
- Air changes (per hr): 12 to 14 times per hour (pre-filtered air: 5 - 10 µ)
- Photoperiod (hrs dark / hrs light): lighting is artificial for 12 hours per day
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The left eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg - Duration of treatment / exposure:
- The upper and lower eyelids are held together for ten seconds after administration to avoid any loss of test substance.
3 rabbits: wash-out after 4 seconds
3 other rabbits: wash-out after 30 seconds - Observation period (in vivo):
- The examinations are always carried out under the same conditions in particular for the lighting. They are made by comparison with the control eye, 1hour after the instillation, and then 24, 48 and 72 hours later. For evaluating the reversibility or irreversibility of the lesions the observation period was prolonged for 7 days.
- Number of animals or in vitro replicates:
- 6 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The eyes of 3 rabbits are washed out 4 seconds after the instillation, care being taken not to cause injury, and on the 3 other animals 30 seconds after the pplication of the test substance. About 50 mL of the rinsing solution at about 20°C is administered using a plastic jet at moderate pressure. The control eye is washed out under the same conditions as the treated one. The excess of liquid is immediately wiped away with a Codex hydrophilic gauze pad.
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: hand-slit lamp / Heine's ophtalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24,48, 72 hours
- Score:
- 3.94
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: chemosis
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.89
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 7 days
- Remarks on result:
- other: redness
- Irritant / corrosive response data:
- On day 7 total necrosis of the eye was observed with loss of the vitreous humor of the eye in 3 of 6 rabbits. In the other 3 rabbits, the observed lesions were not reversible.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Under the conditions of the test the substance was observed to be severely irritating. Based on the criteria of the CLP Regulation, the substance is classified as Irreversible effects on the eye category 1.
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