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EC number: 255-485-3 | CAS number: 41669-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- phototoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 23 - 24 Jan 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
- Principles of method if other than guideline:
- Evaluation of skin reactions after dermal application of the test substance which was subsequently exposed to UV radiations (UVA + UVB).
- GLP compliance:
- yes
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Isooctadecyl isooctadecanoate
- EC Number:
- 255-485-3
- EC Name:
- Isooctadecyl isooctadecanoate
- Cas Number:
- 41669-30-1
- Molecular formula:
- C36H72O2
- IUPAC Name:
- 2-methylheptadecyl 3-methylheptadecanoate
- Details on test material:
- - Name of test material (as cited in study report): [only trade name given]
- Physical state: thick liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Maury, Villefranche de Lonchat
- Weight at study initiation: about 300 g
- Housing: The animals were kept in groups of 3 in Makrolon boxes (46.5 x 31 x 19 cm), the floor of which was covered with clean saw dust. A guinea pig feeding device and a drinking bottle were fixed to the stainless steel wired lid.
- Diet: UAR 106, ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 ± 2
- Humidity (%): 55 ± 10
- Air changes (per hr): 14
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- TEST SITE
- Area of exposure: 1 cm²
- Time intervals for shavings or clipplings: at least 72 h prior to application of the test material
TEST MATERIAL
- Amount applied: 0.02 mL
USE OF RESTRAINERS FOR PREVENTING INGESTION: no - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 30 min prior to UV irradiation
1603 s UVA irradiation
58 s UVB irradiation - Frequency of treatment:
- single application without washing
- Post exposure period:
- 24 h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.02 mL/cm²
Basis:
other: actual amount applied
- No. of animals per sex per dose:
- 10
- Control animals:
- other: only UVA and UVB irradiated sites of the same animal served as control
- Details on study design:
- PREPARATION OF THE ANIMALS
Prior to the application of the test material and UV irradiation, animals were slightly anaesthetised with Ketamine (0.1 g/kg bw of chlroketam Vétoquinol) for immobilisation, and the clipped skin was hot wax depilated.
IRRADIATION SOURCES
Irradiations were performed using Philips tubes:
- TL 20W/09 N for UVA irradiations
- TL 20W/12 UV for UVB irradiations
Radiation levels were measured with a UVx Wilber Lourmat radiometer.
The exposure times chosen corresponded to radiation doses (in mW/cm²) of UV (A+B) which allowed working at suberythematous levels:
- 1603 s for irradiations with TL 20W/09 N tubes, corresponding to 3302.18 mJ/cm² UVA energy and 224.42 mJ/cm² UVB energy.
- 58 s for irradiations with TL 20W/12 UV tubes, corresponding to 17.4 mJ/cm² UVA energy and 62.64 mJ/cm² UVB energy.
TREATMENTS
The clipped and depilated area (back and flanks) was divided in 6 areas of 1 cm² (3 on both sides of the vertebral axis).
Area 1: Test material + UVA
Area 2: Test material + UVB
Area 3: Test material
Area 4: Positive control (8-metoxypsoralene + UVA
Area 5: UVA
Area 6: UVB
Examinations
- Examinations:
- EVALUATION OF SKIN REACTIONS
Animals were observed for skin reactions 24 h post-treatment. The degree of induced erythema and/or edema was evaluated according to the Draize scoring system for skin irritation.
For each of the 6 areas the mean score was calculated.
INTERPRETATION OF RESULTS
The test material was considered as phototoxic if the average of the scores obtained with the test substance, after UVA or UVB irradiation, was significantly higher that that of the corresponding control areas, which were only UVA or UVB irradiated. - Positive control:
- 8-metoxypsoralene + UVA
Results and discussion
- Details on results:
- No significant skin reactions was observed on the sites treated with the test material, whether exposed to UV radiation or not.
Under the same conditions, the sites treated with the positive control 8-MOP showed major reactions.
The test substance, therefore, devoid of phototoxic effects under the experimental conditions adopted.
Applicant's summary and conclusion
- Conclusions:
- Not phototoxic
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