Registration Dossier
Registration Dossier
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EC number: 418-280-1 | CAS number: 18600-59-4 CYASORB(R) UV-3638 LIGHT STABILISER
Toxicity to reproduction
Administrative data
- Endpoint:
- one-generation reproductive toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EC Annex V,B.7
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
- EC Number:
- 418-280-1
- EC Name:
- 2,2-(1,4-phenylene)bis((4H-3,1-benzoxazine-4-one)
- Cas Number:
- 18600-59-4
- Molecular formula:
- C22H12N2O4
- IUPAC Name:
- 2-[4-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-4H-3,1-benzoxazin-4-one
Constituent 1
Test animals
- Species:
- other: Sprague-Dawley (Crl: CD VAF)
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: methylcellulose
- Details on exposure:
- Method of administration or exposure: 7 days a week by gavage from start to euthanasia.
- Analytical verification of doses or concentrations:
- not specified
- Frequency of treatment:
- Dosing regime (males): 7days/week
Dosing regime (females): 7days/week
- No. of animals per sex per dose:
- Male: 30 animals at 0 mg/kg or mg/l
Male: 30 animals at 10 mg/kg or mg/l
Male: 30 animals at 150 mg/kg or mg/l
Male: 30 animals at 1000 mg/kg or mg/l
Female: 30 animals at 0 mg/kg or mg/l
Female: 30 animals at 10 mg/kg or mg/l
Female: 30 animals at 150 mg/kg or mg/l
Female: 30 animals at 1000 mg/kg or mg/l
Results and discussion
Results: P0 (first parental generation)
Details on results (P0)
dose nr. of life pups/litter (day 0)
0 15.3
10 16.5
150 15.7
1000 15.8
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- reproductive performance
Results: F1 generation
Details on results (F1)
No treatment related findings.
dose F1 sex ratio viability index
0 51.9 96.9%
10 50.3 98.1%
150 52.8 97.6%
1500 49.1 96.2%
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 1 500 mg/kg bw/day
- Sex:
- male/female
- Basis for effect level:
- viability
- other: sex ratio
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
