Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-817-5 | CAS number: 126-98-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Handbook data reports the substance as non-sensitising in the guinea pig. However, further animal testing is contraindicated by clear systemic toxicity and industrial risk management measures designed to prevent exposure.
Migrated from Short description of key information:
Non-sensitising (handbook data)
Sensitising (harmonised classification)
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data
Migrated from Short description of key information:
No data
Justification for classification or non-classification
The harmonised classification declaring methacrylonitrile to be a skin sensitiser (category 1) is included as required by Regulation (EC) 1272/2008 even though additional animal testing, which would provide the data necessary to confirm that classification, is ruled out on the grounds of systemic toxicity in vertebrates. Expert opinion considers that methacrylonitrile is unlikely to meet criteria for classification as a skin sensitiser under the terms of Directive 67/548/EEC or GHS as reflected by Regulation (EC) 1272/2008. This conclusion is supported by the fact that structurally related methacrylates are known to have a low potential for sensitisation. There is also a lack of methodological evidence for the published 0.2 % threshold.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
