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EC number: 611-591-5 | CAS number: 57903-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study is equivalent or similar to OECD Guideline 414, but only a single dose was tested, which did not cause maternal toxicity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- no
Test material
- Reference substance name:
- 3525-68-3
- IUPAC Name:
- 3525-68-3
- Details on test material:
- - Name of test material (as cited in study report): C-253
- Physical state: amber, crystalline solid
- Analytical purity: 100 %
- Lot/batch No.: 3-81
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: CRL:COBS CD (SD)BR
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Inc. Kingston New York
- Age at study initiation: 12-14 and 8-10 weeks
- Housing: individually
- Diet (e.g. ad libitum): Purina rodent Laboratory Chow, ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: 12 days
ENVIRONMENTAL CONDITIONS
- Temperature: 74 °F (S.D. = 0.4)
- Humidity (%): 40 (S.D. = 8.0)
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: Test material was heated in a water bath to liquified, corn oil was assed and stirred into solution.
- Details on mating procedure:
- 1 male per 2 females were placed in breeding cage for max. of 2 weeks.
Maiting confirmd by the presecne of a vaginal plug or by examination of vaginal smears for the presence of sperm.
The day mating was confirmed was designated as day 0 for each female. - Duration of treatment / exposure:
- 10 days, from Days 6 through 15 of gestation
- Frequency of treatment:
- once daily
- Duration of test:
- 28 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10 mg/kg bw
Basis:
nominal conc.
- No. of animals per sex per dose:
- 15 male and 29 female rats
25 female rats for the treatment group - Details on study design:
- - Dose selection rationale: Based on the results of a range-finding study
- Rationale for animal assignment: Random
Examinations
- Maternal examinations:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: daily
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: from day 0 through 20 of gestation
BODY WEIGHT: Yes
- Time schedule for examinations: Day 0, 6, 9, 12, 15 and 20 of gestation
POST-MORTEM EXAMINATIONS: Yes
- Sacrifice on gestation day 20 - Ovaries and uterine content:
- The ovaries and uterine content was examined after termination: Yes
Examinations included:
- Gravid uterus weight: Yes
- Number of corpora lutea: Yes
- Number of implantations: Yes
- Number of early resorptions: Yes
- Number of late resorptions: Yes - Fetal examinations:
- - External examinations: Yes: [all per litter]
- Soft tissue examinations: Yes: [two-thirds per litter ]
- Skeletal examinations: Yes: [ two-thirds per litter ]
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Details on maternal toxic effects:
- one femalt died on Day 15 of gestation, no abnormals findings were noted at necropsy, death may be attributet to treatment.
- clinical obxervations were alopecia and wheezing
- Body weights and weight changes were within normal limits
- Food an water consumption were within normal limits.
- pregnancy rate, the mean numbers of corpora lutea and implantations, and the mean implantation efficiency were within normal limits.
- Mean gravid and nongravid uterine weights were within normal limits.
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
No test substance related adverse effects were observed on fetal viability, weights, sex or during visceral or sceletal examinations.
Effect levels (fetuses)
- Dose descriptor:
- NOAEL
- Effect level:
- 10 mg/kg bw/day
- Basis for effect level:
- other: teratogenicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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