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EC number: 224-339-0 | CAS number: 4316-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- OECD Guideline for Testing of Chemicals No. 201 "Alga, Growth Inhibition Test" adopted June 7, 1984
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Test substance: Metaupon, OMT-Paste Konz.
CAS-Number: 91673-22-2
Supplier: Leuna-Werke AG
Batch Number: 090491
Analysis Ref.: TGL 35682
Purity: techn. approximately 51 % - Details on test solutions:
- The stock solution was prepared once before the beginning of the test. The amount of test material used was 500.2 mg. The test material was dissolved in 1 L twice glass distilled water and stirred for 20 min. The nominal concentration of the stock solution was 500.2 mg/L. pH-value: 8.9. Storage conditions: Temperature: room temperature, Duration: approx. 30 min in light.
The nominal concentrations to which the test organisms were exposed were 10, 25, 60, 150 and 360 mg/L. - Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Chodat, SAG 86.81, green alga
Supplier: Institute of plant physiology, University of Goettingen, Goettingen, Germany.
Solid and liquid stock cultures of S. subspicatus have been cultured at Battelle Europe since August 1987. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- Temperature in the test solutions during the period of the test: 22.9 / 23 °C min/max
- pH:
- pH value during the period of the test: 7.9 / 8.4 min/max
- Details on test conditions:
- Exposure conditions
- Age of the pre-culture: 4 d
- Number of cells per mL in the pre-culture before inoculating the test solutions: 4.1E5
- Volume of pre-culture containing 1E6 cells: 2.439 mL
- pH-value of the concentrated algal medium II: 8.3
- Test vessels: 300 mL Erlenmeyer flasks containing 100 mL test solution covered with a cotton plug
- Number of cells per mL test solution at the beginning of the test: 1E4
- Number of replicates per test substance concentration: 4
- Number of replicates in the control: 4
- Light: light/dark (24/0 h) OSRAM L36W/25 (universal white)
- Quantum flux density: 120 +/- 10 µE/s/m² (400 - 700 nm)
- Shaker: 80 +/- 1 oscillations/min
- Temperature in the test room (average value): 23 +/- 1 °C - Reference substance (positive control):
- yes
- Remarks:
- Reference substance: Potassium dichromate (K2Cr2O7)
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- EbC50
- Effect conc.:
- 51 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- EbC50
- Effect conc.:
- 38 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- ErC50
- Effect conc.:
- 156.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- ErC50
- Effect conc.:
- 114.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- EbC50
- Effect conc.:
- 34.7 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Based on actual (measured) concentrations at the end of the test (on average 68% of nominal)
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- EbC50
- Effect conc.:
- 25.8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Based on actual (measured) concentrations at the end of the test (on average 68% of nominal)
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Remarks:
- ErC50
- Effect conc.:
- 106.4 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Based on actual (measured) concentrations at the end of the test (on average 68% of nominal)
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- ErC50
- Effect conc.:
- 77.7 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Based on actual (measured) concentrations at the end of the test (on average 68% of nominal)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Remarks on result:
- other: Based on actual (measured) concentrations at the end of the test (on average 68% of nominal)
- Details on results:
- The analytically determined actual concentrations of the test material at the beginning of the study were found to be within the range of 105 % and 117 % with an average of 111.7 %.
The analytically determined stability of the test material after 48 hours of exposure was found to be within the range of 36 % and 95 % of the nominal values with an average of 68 %.
It is thought that the low recoveries for the test substance after an exposure period of 96 hours was caused by biodegradation of the test substance.
Based on nominal concentrations the study resulted in the following values:
NOEC: 10.0 mg/L; EbC50 after 72 hours: 51.0 mg/L; after 96 hours: 38.0 mg/L; ErC50 after 72 hours: 156.4 mg/L; after 96 hours: 114.2 mg/L.
Based on actual (measured) concentrations at the end of the test (on average 68% of nominal) the study resulted in the following values:
NOEC: 6.8 mg/L; EbC50 after 72 hours: 34.7 mg/L; after 96 hours: 25.8 mg/L; ErC50 after 72 hours: 106.4 mg/L; after 96 hours: 77.7 mg/L. - Results with reference substance (positive control):
- Control of the Test System:
Reference substance: Potassium dichromate (K2Cr2O7);
EbC10 (0-96 h): 0.25 mg/L ErC10 (24-96 h): 2.11 mg/L
EbC50 (0-96 h): 1.18 mg/L ErC50 (24-96 h): 3.22 mg/L
Performed in October 1990
EC10 values for potassium dichromate obtained from different laboratories range between 0.9 mg/L and 1.9 mg/L (RUDOLPH and BOJE, 1986). - Validity criteria fulfilled:
- yes
- Conclusions:
- According to OECD guideline 201 the ErC50 and NOEC of sodium N-methyl oleoyl taurinate, derivatives for green algae were determined based on the measured concentration (on average 68 % nominal). The study results in the following values: ErC50 after 72 hours: 106.4 mg/L; after 96 hours: 77.7 mg/L and NOEC: 6.8 mg/L.
- Executive summary:
The guideline study on acute toxicity of the test substance sodium N-methyl oleoyl taurinate, derivatives to algae was carried out according to OECD 201 using the green alga Desmodesmus subspicatus. The study reports the following values based on the measured concentrations at the end of the study (on average 68 % nominal): ErC50 after 72 hours: 106.4 mg/L; after 96 hours: 77.7 mg/L; EbC50 after 72 hours: 34.7 mg/L; after 96 hours: 25.8 mg/L; NOEC: 6.8 mg/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- The estimation is based on EPI Suite, ECOSAR v1.11. Two models are available, the estimation from the class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship).
- Principles of method if other than guideline:
- The estimation is based on ECOSAR v1.11. Two models are available, the estimation from the Class (Aliphatic Amines-acid) and the Baseline Toxicity (neutral organic structure analysis relationship)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- Calculation is based on the structure of N-methyltaurinate
- Name of test material (as cited in study report): Ethanesulfonic acid, 2- (methylamino)-, monosodium salt - Analytical monitoring:
- not required
- Vehicle:
- not specified
- Test organisms (species):
- other: green algae
- Test type:
- other: estimation by calculation
- Water media type:
- not specified
- Total exposure duration:
- 96 h
- Remarks on exposure duration:
- EC50
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- (Aliphatic Amines-acid)
- Effect conc.:
- 75 538.547 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- other: estimation by calculation
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Remarks:
- (Neutral Organic SAR)
- Effect conc.:
- 118 000 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- other: estimation by calculation
- Dose descriptor:
- other: ChV
- Remarks:
- (Aliphatic Amines-acid)
- Effect conc.:
- 16 636.625 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- other: estimation by calculation
- Remarks on result:
- other: ChV (chronic value, QSAR)
- Dose descriptor:
- other: ChV
- Remarks:
- (Neutral Organic SAR)
- Effect conc.:
- 11 328.276 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- other: estimation by calculation
- Remarks on result:
- other: ChV (chronic value, QSAR)
- Details on results:
- ChV = 10^([log (LOEC x NOEC)]/2)
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The aquatic toxicity for green algae of sodium N-methyltaurinate is calculated by ECOSAR. The lowest calculated EC50 is 75.54 g/L (class: Aliphatic Amines-acid). The lowest calculated chronic toxicity value is 11.33 g/L (Neutral organic SAR).
- Executive summary:
The aquatic toxicity for green algae of sodium N-methyltaurinate is calculated by ECOSAR. The lowest calculated EC50 is 75.54 g/L (class: Aliphatic Amines-acid). The lowest calculated chronic toxicity value is 11.33 g/L (Neutral organic SAR). Nevertheless, the estimation by calculation only provides an approximation and cannot replace empirical studies. The EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available.
Referenceopen allclose all
Description of key information
The aquatic toxicity for green algae of sodium N-methyltaurinate is calculated by ECOSAR using the model Aliphatic Amines-acid. The lowest calculated EC50 (96 h) is 75.54 g/L. The lowest chronic toxicity value estimated by calculation (ChV) is 11.33 g/L. The acute toxicity on algae of the read-across substance sodium N-methyl oleoyl taurinate, derivatives was assessed in the guideline study according to OECD 201 using Desmodesmus subspicatus. The study reports the following values based on the measured concentrations at the end of the test (on average 68 % nominal): NOEC: 6.8 mg/L; ErC50, 72 h and 96 h: 106.4 mg/L and 77.7 mg/L.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 77.7 mg/L
- EC10 or NOEC for freshwater algae:
- 6.8 mg/L
Additional information
The aquatic toxicity for green algae of sodium N-methyltaurinate is calculated by ECOSAR using the model Aliphatic Amines-acid. The lowest calculated EC50 (96 h) is 75.54 g/L. The lowest chronic toxicity value estimated by calculation (ChV) is 11.33 g/L.
The acute toxicity on algae of the read-across substance sodium N-methyl oleoyl taurinate, derivatives was assessed in the guideline study according to OECD 201 using Desmodesmus subspicatus. According to the study, the NOEC is 6.8 mg/L and the ErC50 (72 h and 96 h) is 106.4 mg/L and 77.7 mg/L, respectively.
The empirically determined toxicity of sodium N-methyl oleoyl taurinate, derivatives is lower than the estimated EC50 (96 h) of sodium N-methyltaurinate. The EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. Nevertheless, both the empirical and estimated values are rather high, so that the studies on the read-across substance support the results of the EPI Suite estimation. Therefore, we conclude that the aquatic toxicity data of sodium N-methyl oleoyl taurinate, derivatives provide a reasonable measure to estimate the toxicity of sodium N-methyltaurinate on green algae.
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