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EC number: 939-717-7 | CAS number: 1474044-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February - April 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Methods generally follow accepted procedures for acute oral toxicity studies. The number of animals tested (10) exceed current requirements and the result is considered statistically valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA, CFR Title 21, para. 191.1
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- yes
Test material
- Reference substance name:
- 50% Calcium DNNSA (CAS 57855-77-3)
- IUPAC Name:
- 50% Calcium DNNSA (CAS 57855-77-3)
- Details on test material:
- A dark brown viscous liquid identified as NASUL 729
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The rats were fasted for 18 hours and then individually and singly dosed by gavage
with 5 ml /kg body weight of test material. The rats were individually caged and observed
for mortal ity or other signs of gross toxicity for 14 days. Food and water were provided ad libitum.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Limit dose of 5000 ml/kg body weight
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 mL/kg bw
- Based on:
- test mat.
- Mortality:
- One male rat died on day 1.
- Clinical signs:
- other: All animals appeared active and healthy.
- Gross pathology:
- No remarkable findings for animal 63 that died on day 1.
Any other information on results incl. tables
Rat-No. |
Sex |
BodyWeight-Initial grams |
Dose ml |
Death Day |
63 |
M |
210 |
1.05 |
1 |
64 |
M |
200 |
1.0 |
Survived |
65 |
M |
225 |
1.12 |
Survived |
66 |
M |
205 |
1.02 |
Survived |
67 |
M |
200 |
1.0 |
Survived |
47 |
F |
228 |
1.14 |
Survived |
48 |
F |
210 |
1.05 |
Survived |
49 |
F |
213 |
1.06 |
Survived |
50 |
F |
219 |
1.10 |
Survived |
51 |
F |
200 |
1.0 |
Survived |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The rats were fasted for 18 hours and then individually and singly dosed by gavage
with 5 ml /kg body weight of test material. The rats were individually caged and observed
for mortal ity or other signs of gross toxicity for 14 days. Food and water were provided ad libitum.
The test material is not toxic at a single oral dose of 5ml/kg. The oral LD50 is > 5g/kg. On an active ingredient basis, the LD50 is > 2.5 mg/kg. - Executive summary:
An oral LD50 was conducted with NASUL 729, 50% Calcium DNNSA (CAS 57855-77-3). Five male and five female Sprague Dawley derived albino rats were fasted for 18 hours and then individually and singly dosed by gavage with 5 ml /kg body weight of test material. No clinical symptoms were reported. One male rat died on day 1. The test material was considered not toxic at a single oral dose of 5ml/kg. The oral LD50 is > 5g/kg. On an active ingredient basis, the LD50 is > 2.5 mg/kg.
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