Registration Dossier
Registration Dossier
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EC number: 427-230-8 | CAS number: 5571-36-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EC Directive 67/548/EEC, B.4 OECD Guideline no. 404: Acute Dermal Irritation/Corrosion
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 427-230-8
- EC Name:
- -
- Cas Number:
- 5571-36-8
- Molecular formula:
- C20H26O3
- IUPAC Name:
- (3bS,11aS)-11a-methyl-1,2,3,3a,3b,4,5,6,8,9,11,11a-dodecahydrospiro[cyclopenta[a]phenanthrene-7,2'-[1,3]dioxolan]-1-one
Constituent 1
Test animals
- Species:
- other: albino rabbit, New Zealand White, (SPF-Quality)
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0 (related to all animals)
- Other effects:
- No skin irritation was caused by 4 hours exposure to
ethylene deltenone.
There was no evidence of a corrosive effect on the skin.
No staining of the treated skin by the test substance was
observed.
No symptoms of systemic toxicity were observed in the
animals during the test period and no mortality occurred.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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