Registration Dossier
Registration Dossier
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EC number: 233-820-4 | CAS number: 10377-48-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only handbook or published data available.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Acute Oral Toxicity
- Author:
- Walum, E.
- Year:
- 1 998
- Bibliographic source:
- Environ. l Health Persp. 106, Suppl. 2, 497, 1998
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Only handbook or published data available. No guideline indicated.
- GLP compliance:
- not specified
- Test type:
- other: not indicated
Test material
- Reference substance name:
- Lithium sulphate
- EC Number:
- 233-820-4
- EC Name:
- Lithium sulphate
- Cas Number:
- 10377-48-7
- Molecular formula:
- H2O4S.2Li
- IUPAC Name:
- lithium sulphate
- Reference substance name:
- lithium sulfate
- IUPAC Name:
- lithium sulfate
Constituent 1
Constituent 2
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 613 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The publication of Walum et al. states a LD50 value of 613 mg/kg bw for rats.
- Executive summary:
The publication was used to analyse the predictive power of animal tests for human toxicity. The Scandinavian Society of Cell Toxicology used lithium sulfate as one out of 50 reference substances. The LD50 value for rats was determined out of several studies and defined as 613 mg/kg bw.
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