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EC number: 298-364-0 | CAS number: 93803-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
There are no data available on the aquatic toxicity of 2,2-bis[[(1-oxoisononyl)oxy]methyl]-1,3-propanediyl diisononanoate (CAS 93803 -89 -5). In order to fulfil the standard information requirements set out in Annex VII - IX, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from one structurally related substance was conducted.
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.
Ecotoxicological parameters for the aquatic toxicity of the target substance 2,2-bis[[(1-oxoisononyl)oxy]methyl]-1,3-propanediyl diisononanoate (CAS 93803 -89 -5) and the source substances are presented in the following table.
|
Target |
Source 1 |
CAS |
93803 -89-5 |
131459-39-7 |
Chemical Name |
2,2-bis[[(1-oxoisononyl)oxy]methyl]-1,3-propanediyl diisononanoate. |
3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid |
MW |
697.04 |
472.62 - 697.04 |
Fatty acid chain length |
C9iso |
C5-C6 |
Alcohol |
dipentaerythritol |
dipentaerythritol |
Short-term toxicity to fish |
RA: CAS 131459-39-7 |
EL50 > 100 mg/L |
Long-term toxicity to fish |
Waiving based on Chemical Safety Assessment |
-- |
Short-term toxicity to aquatic invertebrates |
RA: CAS 131459-39-7 |
EL50 > 1000mg/L |
Long-term toxicity to aquatic invertebrates |
-- |
-- |
Toxicity to aquatic algae |
RA: CAS 131459-39-7 |
EL50 > 100 mg/L |
Toxicity to microorganisms |
NOEC (14 d) ≥ 29.1 mg/L |
EC50 > 1000 mg/L |
The above mentioned substances are considered to be similar on the basis of structural similarity resulting in similar properties and/or activities. The available endpoint information is used to predict the same endpoints forPE tetraester with isononanoic acid.
A detailed analogue approach justification is provided in the technical dossier (see IUCLID section 13).
In accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5, grouping and read-across, the target substance 2,2-bis[[(1-oxoisononyl)oxy]methyl]-1,3-propanediyl diisononanoate (CAS 93803-89-5) and the source substance 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) are not considered to be harmful to aquatic organisms based on the results from short-term studies with fish, aquatic invertebrates and algae.
The target and the source substance are structurally similar characterised by thesame alcohol component (pentaerythritol) and similar fatty acid chain lengths, respectively.
Based on the structural, physico-chemical and ecotoxicological similarities, reading across between target and source substance is justified. As it can be seen in the data matrix including all relevant available ecotoxicological data, none of the substances lie out of the ecotoxicological profile, showing a consistent pattern of results.
One acute toxicity study to fish according to internationally accepted guidelines for the source substances 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) is available.The substance consist of the same alcohol component (pentaerythritol) and similar fatty acid chain lengths (C9iso for the target substance compared to C5-6 for the source substances, respectively).No effects were observed up to the limit of water solubility.
One acute toxicity study to invertebrates according to internationally accepted guidelines for the source substances 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) is available.The substance consist of the same alcohol component (pentaerythritol) and similar fatty acid chain lengths (C9iso for the target substance compared to C5-6 for the source substances, respectively).No effects were observed up to the limit of water solubility.
One toxicity study to algae according to internationally accepted guidelines for the source substances 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459 -39 -7) is available. No effects were observed up to the limit of water solubility.
The toxicity to microorganisms was investigated using the ready biodegradability study of the target substance. Additionally, a read across approach with the structurally similar source substance 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was conducted. Based on the results and the structural and profile similarity of the substances, it can be concluded that no effect on the STP microorganism community and the subsequent degradation process in sewage treatment plants is anticipated.
According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance, R.7.8.5.3” (ECHA, 2012), long-term testing of fish should only be conducted if it represents the most sensitive taxonomic group. The Guidance states that if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish. Therefore, no long-term testing on fish is proposed.
In conclusion, no effects on aquatic organisms were observed in the available studies for any of the three trophic levels (fish, daphnia, algae) up to the limit of water solubility.
The available data from a suitable source substance allow for an accurate assessment of the ecotoxicity profile of the target substance 2,2 -bis[[(1 -oxoisononyl)oxy]methyl]-1,3 -propanediyl diisononanoate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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