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Diss Factsheets
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EC number: 922-551-4 | CAS number: 1187440-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: of the alcohol 70-75°C
- Boiling point: >372°C
- Vapour pressure: 6.66 x 10-5 Pa.
- Water solubility (under test conditions): <1mg/L
OTHER PROPERTIES (if relevant for this endpoint)
- Results of test for ready biodegradability: not ready biodegradable - Analytical monitoring:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: special solubilisation method was carried out before the test according to the OECD 203 guidance document on aquatic toxicity testing difficult substances and mixtures - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: danio rerio (Hamilton Buchanan)
- Strain: zebra Fish
- Length at study initiation (length definition, mean, range and SD): 25-30mm
- Feeding during test
- Food type: no feed
ACCLIMATION
- Acclimation period: 12 days
- Acclimation conditions (same as test or not): in the dilution water - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- observation of the mouvement and if the caudal pedencles produce reaction after touching
- Hardness:
- 240 mg/L of Caco3
- Test temperature:
- 21.6 to 23.7°C
- pH:
- 7.1 to 7.8
- Dissolved oxygen:
- 76 to 96 %
- Nominal and measured concentrations:
- 1;10;100mg/L
- Details on test conditions:
- TEST SYSTEM
- Renewal rate of test solution (frequency/flow rate):every 24h
- No. of organisms per vessel: 7 fishes
- No. of vessels per concentration (replicates):1
- No. of vessels per control (replicates):1
- No. of vessels per vehicle control (replicates):1
- Biomass loading rate:1,2g/L
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod:14hours
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : observation of the mouvement and the reaction of the caudal pedencles
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities:
- Observations on body length and weight: none
- Other biological observations: no signs of stress after 96h of test
- Mortality of control: none
- Other adverse effects control:none
- Abnormal responses:none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values:none - Results with reference substance (positive control):
- - Results with reference substance valid?
- Mortality: none
- LC50 (24h) =220mg/L
- Other:in good accordance with the historical data - Reported statistics and error estimates:
- none
- Sublethal observations / clinical signs:
Acute toxicity of the test item LCE07105 was performed on the Zebra fish Danio Rerio, under semi static conditions (test solutions are renewed every 24 hours) and according to the OECD 203 guideline. The result obtained on fishes lethality gives an LC50 -96hours superior to the highest tested concentration, i.e 100mg/L.
This result espressed in mg/L of the nominal concentration shows that no toxicity was observed in the concentrations selected in this test on the Zebra Fish Danio Rerio. No sign of stress was observed on the fishes during 96 hours of the experiment.
In order to control and to confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution contained in the aquarium was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study (as the test was performed with semi static condition, the final sample was aged of 24 hours instead of 96 hours).
Results are presented as follow:
Nominal test Item concentrations in mg/L
totol [P]
at 0h
at 96h
Filtered control
0.028mg/L
100
0.048 mg/L
0.095mg/L
- Validity criteria fulfilled:
- yes
- Conclusions:
- LC50-96hours of the test item "LCE07105" on danio rerio Zebra fish is superior to 100mg/L , value expressed in nominal concentration.
- Executive summary:
Acute toxicity of the test item LCE07105 was performed on the Zebra fish Danio Rerio, under semi static conditions (test solutions are renewed every 24 hours) and according to the OECD 203 guideline. The result obtained on fishes lethality gives an LC50 -96hours superior to the highest tested concentration, i.e 100mg/L.
This result espressed in mg/L of the nominal concentration shows that no toxicity was observed in the concentrations selected in this test on the Zebra Fish Danio Rerio. No sign of stress was observed on the fishes during 96 hours of the experiment.
In order to control and to confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution contained in the aquarium was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study (as the test was performed with semi static condition, the final sample was aged of 24 hours instead of 96 hours).
Results are presented as follow:
Nominal test Item concentrations in mg/L totol [P] at 0h at 96h Filtered control <LOD <0.028mg/L 100 0.048 mg/L 0.095mg/L
Reference
Description of key information
Acute toxicity of the registered substance was performed on the Zebra fish Danio Rerio, under semi static conditions (test solutions are renewed every 24 hours) and according to the OECD 203 guideline. The result obtained on fishes lethality gives an LC50 -96hours superior to the highest tested concentration, i.e 100mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.