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Diss Factsheets
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EC number: 209-708-6 | CAS number: 591-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. Department of Transportation, 49 CFR 173.132
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5-dimethylpyridine
- EC Number:
- 209-708-6
- EC Name:
- 3,5-dimethylpyridine
- Cas Number:
- 591-22-0
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3,5-dimethylpyridine
- Test material form:
- other: liquid
- Details on test material:
- sourced from Nepera Co.. Colorless liquid. Specific gravity: 0.95. The article was stored at room temperature and humidity.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were quarantined for at least 1 week. The animals were born between the weeks of 8/4/98 and 8/25/98. The pretest body weight range was 237-292 g for males and 211-221 g for females. Animals were housed 5/sex/cage in suspended wire mesh cages. Bedding was placed beneath the cages and changed at least 3 times/week. Food was fresh Purina Rat Chow (diet #5012) and was available ad libitum except for 16-20 h prior to dosing. Water was available ad libitum. The animal room was temperature controlled, had a 12 h light/dark cycle and was kept clean and vermin free.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The dose was based on the sample weight as calculated from the specific gravity. All rats received the same concentration of dosing solution.
- Doses:
- 500 mg/kg body weight.
- No. of animals per sex per dose:
- 5/sex/dose group
- Control animals:
- no
- Details on study design:
- Animals were observed 3-4 h post dose and once daily thereafter for 14 days for mortality, toxicity and pharmacological effects. Body weights were recorded pretest and at termination.
Animals were examined for gross pathology, post mortem. Tissues were not preserved. - Statistics:
- No statistical analysis was undertaken.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- < 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 3 males and 5 females died by day 2.
- Mortality:
- 3 Males and 5 females (of 10 animals total) died by day 2.
- Clinical signs:
- other: Physical signs included dyspnea, soiling of the anogenital area, flaccid muscle tone, lethargy, prostration, negative righting reflex, ataxia, diarrhea, wetness of body areas, nasal discharge and brown staining of the nose/mouth area. Physical signs amon
- Gross pathology:
- Necropsy results in the dead animals revealed abnormalities of the eyes, lungs, liver, kidneys, spleen and gastrointestinal tract. Necropsy results in the surviving animals were normal.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information The LD50 is less than 500 mg/kg bw. Criteria used for interpretation of results: EU
- Conclusions:
- The substance, when given by oral gavage to Wistar rats, displayed an LD50 of less than 500 mg/kg bw.
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