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EC number: 433-360-6 | CAS number: 34036-80-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- 2-butanone-O,O',O''- (phenylsilylidyne)trioxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriols undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to butanone oxime and their values are comparable.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: Read-across
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Principles of method if other than guideline:
- Read-across approach from experimental data (test method similar to OECD Guideline 408, GLP study) on an analogue substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- 96-26-7
- IUPAC Name:
- 96-26-7
- Reference substance name:
- Butanone oxime
- EC Number:
- 202-496-6
- EC Name:
- Butanone oxime
- Cas Number:
- 96-29-7
- Molecular formula:
- C4H9NO
- IUPAC Name:
- butan-2-one oxime
- Details on test material:
- - Name of test material (as cited in study report): Methyl ethyl ketoxime
- Molecular formula (if other than submission substance): C4H9NO
- Molecular weight (if other than submission substance): 87.12
- Smiles notation (if other than submission substance): CC(CC)=NO
- InChl (if other than submission substance): 1/C4H9NO/c1-3-4(2)5-6/h6H,3H2,1-2H3
- Structural formula attached as image file (if other than submission substance): see Fig.
Constituent 1
Constituent 2
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- no effects observed
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Gross pathological findings:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- Based on experimental results obtained with the analogue substance butanone oxime in rats after 13 weeks oral administration where the NOAEL for erythrotoxicity was 312 ppm and the NOAEL for olfactory epithelium degeneration was 1250 ppm, the read-across approach was applied and the NOAEL for the 2-butanone-O,O',O''-(phenylsilylidyne)trioxime was estimated to be 433.93 ppm for erythrotoxicity and 1738.50 ppm for olfactory epithelium degeneration.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Remarks:
- (erythrotoxicity)
- Effect level:
- 433.93 ppm
- Based on:
- test mat.
- Remarks:
- (analogue subtance)
- Sex:
- male/female
- Basis for effect level:
- other: (based on read-across approach from experimental data on analogue butanone oxime) (basis for effect: anemia)
- Dose descriptor:
- NOAEL
- Remarks:
- (nose)
- Effect level:
- 1 738.5 ppm
- Based on:
- test mat.
- Remarks:
- (analogue substance)
- Sex:
- male/female
- Basis for effect level:
- other: (based on read-across approach from experimental data on analogue butatone oxime) (basis for effect: olfactory epithelium degeneration)
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The concentrations used in the study on the analogue substance and the read-across approch estimation are as follows:
Unit |
Sex |
MEKO |
POS |
ppm rats |
Male/female |
312,00 |
433,93 |
625,00 |
869,25 |
||
1250,00 |
1738,50 |
||
2500,00 |
3477,00 |
||
5000,00 |
6954,01 |
||
mg/kg bw/day |
Male |
25,00 |
34,77 |
50,00 |
69,54 |
||
100,00 |
139,08 |
||
175,00 |
243,39 |
||
280,00 |
389,42 |
||
mg/kg bw/day |
Female |
30,00 |
41,72 |
65,00 |
90,40 |
||
120,00 |
166,90 |
||
215,00 |
299,02 |
||
335,00 |
465,92 |
Meko = Butanone oxime
POS = 2-butanone-O,O',O''-(phenylsilylidyne)trioxime
See "Data Matrix" and "Reporting Format" attached.
Applicant's summary and conclusion
- Conclusions:
- Based on the read-across approach from experimental results on analogue butanone oxime, the NOAEL for 2-butanone-O,O',O''-(phenylsilylidyne)trioxime for 13 weeks repeated dose toxicity by oral route in rats was estimated to be 433.93 ppm (34.77 and 41.72 mg/kg bw/day for males and females respectively) for erythrotoxicity and 1738.50 ppm (139.08 and 166.90 mg/kg bw/day for males and females respectively) for olfactory epithelium degeneration.
- Executive summary:
A 90 days repeated dose toxicity test was performed on analogue substance butanone oxime in accordance with an equivalent method to OECD Guideline 408. After 13 weeks oral administration of analogue MEKO to rats up to 5000 ppm (up to 280 mg/kg bw/day in males and up to 335 mg/kg/bw/day), the NOAEL for erythrotoxicity was determined to be 312 ppm (25 and 30 mg/kg bw/day in males and females respectively) and the NOAEL for olfactory epithelium degeneration was determined to be 1250 ppm (100 and 120 mg/kg bw/day in males and females respectively). Based on these results, the read-across approach was applied and the NOAEL for 2-butanone-O,O',O''-(phenylsilylidyne)trioxime for 13 weeks repeated dose toxicity by oral route in rats was estimated to be 433.93 ppm (34.77 and 41.72 mg/kg bw/day for males and females respectively) for erythrotoxicity and 1738.50 ppm (139.08 and 166.90 mg/kg bw/day for males and females respectively) f or olfactory epithelium degeneration.
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