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Diss Factsheets
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EC number: 927-913-5 | CAS number: 160844-75-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate
- EC Number:
- 927-913-5
- Cas Number:
- 160844-75-7
- Molecular formula:
- C18H20N2O3S
- IUPAC Name:
- ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese white strain
- Details on test animals or test system and environmental conditions:
- Were placen in an environmentally conditioned room with a temperature with in 21-25ºC, a relative humidity within 45-65%, room air ventilation of approximatelly 15times/hour, and lighting for 12 hours (7:00 to 19:00)
Test system
- Type of coverage:
- other: single closed-patch application
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- The test article was weighted and divided into 0.5g portions and each was wrapped in a piece of paper.
- Duration of treatment / exposure:
- A single closed-patch application for 4 hours
- Observation period:
- Macroscopic examination:
Was carried out at 1, 24, 48 and 72 hours after the 4-hour application period. - Number of animals:
- Five male rabbits of Japanese white strain (Kbs: JW, clean), 16-17 weeks old, weighting 3.21 - 3.35kg
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- other: all three animals
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- other: at 1,24,48 and 72 hours
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- other: at 1,24,48 and 72 hours
- Irritation parameter:
- edema score
- Basis:
- mean
- Score:
- ca. 0
- Max. score:
- 0
- Remarks on result:
- other: at 1,24,48 and 72 hours
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- These results demostrate that Cyano Derivative is evaluated to have no irritation effects on the skin of rabbits under the present test condition.
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