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EC number: 200-870-3 | CAS number: 75-44-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method/guideline followed: Experimental study to investigate lung effects, not an OECDguideline study.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phosgene
- EC Number:
- 200-870-3
- EC Name:
- Phosgene
- Cas Number:
- 75-44-5
- Molecular formula:
- CCl2O
- IUPAC Name:
- phosgene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 4 or 12 weeks for all dose levels
- Frequency of treatment:
- 0.1 ppm for 5 days/week;
0.2 ppm for 5 days/week;
0.5 ppm for 2 days/week;
1.0 ppm for 1 day/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.1 ppm
Basis:
no data
- Remarks:
- Doses / Concentrations:
0.2 ppm
Basis:
no data
- Remarks:
- Doses / Concentrations:
0.5 ppm
Basis:
no data
- Remarks:
- Doses / Concentrations:
1 ppm
Basis:
no data
- Control animals:
- yes
- Positive control:
- clean air only 5 days/week for 4 or 12 weeks.
Examinations
- Statistics:
- Multivariate analysis of variance [MANOVA].
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Description (incidence and severity):
- no lethality, but change of lung weight and displacement volume.
- Mortality:
- no mortality observed
- Description (incidence):
- no lethality, but change of lung weight and displacement volume.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 0.1 ppm
- Based on:
- other: lung weight and displacement volume
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
NOAEL: None
LOAEL: 0.1 ppm (based on lung weight and displacement volume)
Toxic response/effects by dose level: No lethality was reported in any of the exposed groups
Lung weight and displacement volume were significantly changed at 4 weeks, even at the 0.1
ppm exposure concentration. There was no further change at 12 weeks.
Pulmonary histological changes [thickening and inflammation] were associated with phosgene
exposure, at the terminal bronchiolar regions at 0.1 and 0.2 ppm concentrations, and in the more
peripheral areas at 1.0 ppm [the 0.5 ppm samples were inadvertently lost]. The severity of
changes seemed to depend on phosgene concentrations, and not concentration X time of
exposure.
Histopathology following 4 weeks of clean air recovery after 12 weeks of phosgene exposure
indicated almost complete recovery at 0.1 ppm; the 0.2 ppm group appeared to have resolved
considerably; collagen staining remained at the same level of intensity in the 12 weeks group at
0.2 and 1.0 ppm.
Applicant's summary and conclusion
- Conclusions:
- The authors conclude that daily exposure to 0.1 ppm phosgene for 6 hrs/day, 5 days/week, for 4
and 12 weeks can cause subtle histological changes in the lungs of rats. Higher concentrations
cause more pronounced effects, which appear to depend more on phosgene concentration than
time of exposure. No lethality was reported.
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