Registration Dossier
Registration Dossier
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EC number: 223-786-9 | CAS number: 4073-98-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Acutely very toxic for aquatic invertebrates.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.531 mg/L
Additional information
No experimental data are available for 4,4'-methylenebis(2,6-xylidine) (CAS 4073 -98 -7). To assess the toxicity to aquatic invertebrates, read across was made to the analogue substance N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1).
The toxicity of N,N,N',N'-tetramethyl-4,4'-methylenedianiline was tested with the test organism Daphnia magna according to EU Method C.2 (Acute Toxicity for Daphnia). In the tested concentration range the substance was not completely soluble in M4 medium. Furthermore, the analytical recovery rate was in all analyzed test solutions (100 mg/L concentration) below 80%. The effective concentration mentioned in this report are therefore based on a median analytical recovery rate after 0 and 48 hours with daphnids (both: 100 mg/L nominal, 1.4 mg/L found; calculation factor 0.014). According to this, the 48 -h EC50 was determined to be 0.531 mg/L (BASF, 1998; report No. 97/0545/50/1).
Following this, the test substance is assessed to be acutely very toxic for aquatic invertebrates.
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