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Physical & Chemical properties

Partition coefficient

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Administrative data

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29.07.2010 - 22.11.2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to other study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Principles of method if other than guideline:
The partition coefficient was estimated using the solubilities in the pure solvents water and n-octanol. The experimentally determined partition coefficient is outside the range of the published methods in the guidelines and, therefore, no further tests were performed.
GLP compliance:
yes
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Key result
Type:
log Pow
Partition coefficient:
< -3.7
Temp.:
20 °C
pH:
2.4
Details on results:
The water solubilty was determined to be >943 g/L at 20 °C and pH = 2.4.
The solubility in n-octanol was determined to be <0.20 g/L at 20.0 °C.
Estimated log Pow of the test substance (without pH correction): <-3.7
Conclusions:
The logPow of the test substance (without pH correction) was estimated to be <-3.7.
Executive summary:

A study according to OECD 107 and Regulation (EC) No 440/2008 Method A.8 was performed to determine the partition coefficient of the test item. The partition coefficient was estimated using the solubilities in the pure solvents water and n-octanol, due to very high water solubility of the test item. The water solubilty was determined to be >943 g/L at 20 °C and pH = 2.4. The solubility in n-octanol was determined to be <0.20 g/L at 20 °C. The log Pow of the test item (without pH correction) was estimated to be < -3.7. The experimentally determined partition coefficient is outside the range for which methods are published in the guidelines and, therefore, no further tests could be performed.

Description of key information

The logPow of the test substance (without pH correction) was estimated to be <-3.7 (reference 4.7-1).

Key value for chemical safety assessment

Log Kow (Log Pow):
-3.7
at the temperature of:
20 °C

Additional information

A study according to OECD 107 and Regulation (EC) No 440/2008 Method A.8 was performed to determine the partition coefficient of the test item. The partition coefficient was estimated using the solubilities in the pure solvents water and n-octanol, due to very high water solubility of the test item. The water solubilty was determined to be >943 g/L at 20 °C and pH = 2.4. The solubility in n-octanol was determined to be <0.20 g/L at 20 °C. The log Pow of the test item (without pH correction) was estimated to be < -3.7. The experimentally determined partition coefficient is outside the range for which methods are published in the guidelines and, therefore, no further tests could be performed.