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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
1-cyanoallyl acetate
EC Number:
239-743-2
EC Name:
1-cyanoallyl acetate
Cas Number:
15667-63-7
Molecular formula:
C6H7NO2
IUPAC Name:
1-cyanoprop-2-en-1-yl acetate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Housing: individually
- Diet: ad libitum
- Water: ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23
- Humidity (%): 50-60
- Photoperiod (hrs dark / hrs light): 12/12


Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: tragacanth (0.5%)
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 11.2; 13.6; 15; 16.5; 18.1 mg/L
- Amount of vehicle (if gavage): 2.15 ml/kg
- Justification for choice of vehicle: test substance not soluble in water


Doses:
0.024-0.038 mL/kg corresponding to 24.1-39.0 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: no
Statistics:
Probit analysis

Results and discussion

Effect levelsopen allclose all
Sex:
female
Dose descriptor:
LD50
Effect level:
33.7 mg/kg bw
Based on:
test mat.
95% CL:
31.1 - 36.5
Sex:
male
Dose descriptor:
LD50
Effect level:
31.6 mg/kg bw
Based on:
test mat.
95% CL:
28.6 - 34.8
Sex:
male/female
Dose descriptor:
LD50
Effect level:
32.7 mg/kg bw
Based on:
test mat.
95% CL:
30.8 - 34.4
Mortality:
Mortality (if any) was observed within 30 min after administration
males: 24.5 mg/kg bw: 0/5
29.6 mg/kg bw: 1/5
35.7 mg/kg bw: 4/5
38.8 mg/kg bw: 5/5

females: 29.6 mg/kg bw: 0/5
32.6 mg/kg bw: 2/5
35.7 mg/kg bw: 3/5
38.8 mg/kg bw: 5/5
Clinical signs:
other: Clonic (and tonic) convulsions, tremor, decrease of  muscle tone, general loss of reflexes, dyspnea, redness of the skin in females. Symptoms appeared 2 min after administration and persisited in surviving animals 1 to 6 h.
Gross pathology:
Only red decoloration of mucosa of the gastrointestinal tracts observed in some animals. No other changes were found.

Applicant's summary and conclusion

Interpretation of results:
Category 2 based on GHS criteria
Remarks:
Migrated information