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Diss Factsheets
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EC number: 233-796-5 | CAS number: 10361-80-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1980-07-29 - 1980-07-31
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- GLP study with relevant methodological deficiencies: scoring limited to 24 and 48h, no details on scoring system (presumably limited to corrosive yes/no). No conclusion can be drawn on the irritating potential of the mixture or the substances in the mixture.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- no details on test animals and conditions, observations limited to 24h and 48h after exposure, no details on scoring system
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: procedure specified in Title 49, CFR articles 173.240, Appendix A
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Solution of 70% Praseodymium and 30% Neodymium
- IUPAC Name:
- Solution of 70% Praseodymium and 30% Neodymium
Constituent 1
- Specific details on test material used for the study:
- - Batch number: 10238-2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Margaret's Home Farm Athol, Massachusetts
- Age at study initiation: no data
- Weight at study initiation: range: 2.0 - 2.5 kg
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Patches were removed after 4 hours and scored for destruction or irreversible alteration of the skin. The test sites were again observed at 24 and 48 hours.
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: animal's right side at two sites, covered with cotton gauze and secured with tape.
REMOVAL OF TEST SUBSTANCE
Patches were removed after 4 hours and scored for destruction or irreversible alteration of the skin. The test sites were again observed at 24 and 48 hours.
SCORING SYSTEM:
If the test substance corrodes the skin of two or more rabbits, the sample is considered corrosive (Title 49 CFR 173.240)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corrosivity
- Basis:
- other: all animals
- Time point:
- other: 24 and 48h
- Score:
- 0
- Reversibility:
- no data
- Irritant / corrosive response data:
- Based on the standards set by Title 49 CFR 173.240, the solution of Praseodymium 70%, Neodymium 30% does not cause skin corrosion.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Due to the lack of a scoring system, the conclusion cannot be firmly validated and confirmed on the skin irritation/corrosion potential of the mixture or its constituents.
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