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EC number: 208-584-0 | CAS number: 534-03-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) = 3.99 mg/L for Daphnia magna (OECD 211); read-across
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.99 mg/L
Additional information
There are no data available on long-term toxicity of 2-amino-1,3-propanediol (APD) to aquatic invertebrates. However, there are reliable data for another member of the chemical category APD belongs to. Therefore, read-across was performed based on a category approach. Within this chemical category, the members are APD, 2-amino-2-methyl-1,3-propanediol (AMPD) and 2-amino-2-ethyl-1,3-propanediol (AEPD), collectively called aminopropanediols. All the members contain a propane backbone carrying the same functional groups, one primary amine group and two hydroxyl groups, at the same position. The three category members differ only in the length of the alkyl side chain, which contains 0, 1 or 2 carbon atoms for APD, AMPD and AEPD, respectively.
Structural similarities of all category members, as well as similarities of short term toxicity results for all three taxonomic groups justify the read across from AEPD to APD in the case of long term toxicity to daphnia.
Both APD and AEPD are well soluble in water (> 900 g/L) and have a very low vapour pressure (0.01 Pa). The relatively low partition coefficient (log Kow) of -1.82 (APD) and -1.02 (AEPD) result in a low potential to accumulate in biological systems. Also the log Koc is low for both substances, 2.96 and 2.31 for AEPD and APD respectively. Acute aquatic toxicity of > 100 mg/L indicates that both substances have low toxic potential to aquatic organisms. By calculating potential metabolites via OECD QSAR toolbox v.2.0 (2010), no relevant metabolites were predicted by the liver metabolism simulator, by the skin metabolism simulator, or by the microbial metabolism simulator. The Cramer classification (related mainly to oral route) also indicates that no metabolism by cytochrome P450 enzymes in vivo is expected for APD and AEPD.
Both OASIS and ECOSAR classification models indicate narcosis as mode of action for all category members, however it is known that for amines the toxicity can be enhanced with respect to baseline and the mode of action can be classified as “amine narcosis”. Nevertheless, as in the general case of narcosis (i.e. with absence of specific and reactive effects – which is confirmed by the presence of only amine and alcohol functional groups), log Kow is the main toxicity trigger, which is very low for both substances.
In the ready biodegradation test (301F), APD reached 100% degradation within 5 days. AEPD is not readily biodegradable, but was rapidly degraded in the inherent test (> 90% with 7 days) and thereby represents the worst case for long-term effects, in comparison to APD.
The study with AEPD was conducted according the OECD guideline 211 and GLP (MOE, 2004). The test organism Daphnia magna was exposed to AEPD in a semi-static system for 21 days, at the test concentrations 3.99, 8.61, 18.7, 41.1, 88.5 mg/L (TWA). A NOEC based on reproduction of 3.99 mg/L was obtained.
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