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Diss Factsheets
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EC number: 202-852-0 | CAS number: 100-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test methodology according to a standard protocol in a reliable corporate laboratory, but not performed under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. 49 CFR Subpart D, 173, 136-137
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-vinylpyridine
- EC Number:
- 202-852-0
- EC Name:
- 4-vinylpyridine
- Cas Number:
- 100-43-6
- Molecular formula:
- C7H7N
- IUPAC Name:
- 4-ethenylpyridine
- Test material form:
- other: clear liquid
- Details on test material:
- Tested as received
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- After acclimation, 6 NZW rabbits (3 males/3 females) were identified by a number allocated to each on receipt and stainless steel ear tag bearing this number. They were selected after a 10 day rest period. They were caged individually in suspended stainless steel cages with mesh floors. Room temperature was 70-73 degrees F. Food was Purina Rabbit Chow. Water was filtered tap water supplied by an automatic water system.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of test material applied to a 2.5 cm2 intact site.
- Duration of treatment / exposure:
- 3 minutes or 1 hour
- Observation period:
- 48 hours
- Number of animals:
- 6 animals
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm2
- % coverage:
- Type of wrap if used: 2 x 2 in adhesive-backed gauze patch, secured in place with 2 inch non-irritating Durapore tape to minimize evaporation.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped clean to prevent further exposure
- Time after start of exposure: 3 minutes or 1 hour
SCORING SYSTEM: Evaluation of corrosion: presence of destruction or irreversible alteration of the tissue in at least 2 of 6 animals. Tissue destruction was considered to have occurred if there was ulceration and/or necrosis.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: corrosion
- Basis:
- other: Considered positive if 2 of 6 animals showed corrosion.
- Time point:
- other: 48 hours after administration
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- other: No corrosion evident after a 3 minute exposure
- Irritation parameter:
- other: Corrosion
- Basis:
- other: Considered positive if 2 of 6 animals showed corrosion.
- Time point:
- other: 48 hours
- Score:
- 3
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: 3 of 6 animals showed corrosion after a 1 hour exposure
- Irritant / corrosive response data:
- 4-Vinylpyridine is considered corrosive when evaluated 48 hours after a 1 hour exposure
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 4 -Vinylpyridine was corrosive to the skin of rabbits after a 1 hour exposure. This meets the criteria of CLP Category 1B.
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