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EC number: 251-646-7 | CAS number: 33703-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 22 May - 12 Jun 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See explainations in the endpoint study summary and the analogue justification document attached in chapter 12. - Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- > 0.77 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction and survival
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See explainations in the endpoint study summary and the analogue justification document attached in chapter 12. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 4.4 µg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- other: reproduction, growth, mortality
- Remarks on result:
- other: saturated test solution tested
Referenceopen allclose all
Description of key information
With high probability diisononyl adipate is chronically not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Since no study assessing the long-term toxicity of DINA to aquatic invertebrates is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to structurally very similar Bis(2-ethylhexyl) adipate (CAS 103-23-1, DEHA) was conducted. The read across is justified due to the similarity of structure and functional groups and accordingly similar physico-chemical properties which result in similar environmental behavior and fate (see table below).
Substance |
Diisononyl adipate (DINA) |
Bis(2-ethylhexyl) adipate (DEHA) |
CAS number |
33703-08-1 |
103-23-1 |
Structure |
see attachment |
see attachment |
Molecular formula |
C24H46O4 |
C22H42O4 |
Molecular weight |
398.63 g/mole |
370.58 g/mole |
PC parameter |
|
|
Water solubility |
RA to 103-23-1 |
0.0032 mg/L (EU A.6) |
Partition coefficient |
9.54 (OECD 117) |
8.94 (OECD 117) |
Vapour pressure |
0.00000002 hPa at 20 °C (calculation) |
0.0000003 hPa at 20 °C (calculation) |
Environmental fate |
|
|
Biodegradability |
> 90% in 28 days (OECD 301F) |
>90% in 28 days (OECD 301F) |
Adsorption [log KOC] |
5.15 (calculation) |
4.56 (calculation) |
Hydrolysis |
not relevant |
|
Ecotoxicology |
|
|
Short-term toxicity to fish [96h-LC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to aquatic invertebrates [NOEC] |
- |
- |
Short-term toxicity to aquatic invertebrates [48h-EC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to aquatic invertebrates [21d-NOEC] |
RA drom 103 -23 -1 |
No toxicity within the limit of water solubility |
Short-term toxicity to algae [72h-EC50] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Long-term toxicity to algae [72h-NOEC/EC10] |
No toxicity within the limit of water solubility |
No toxicity within the limit of water solubility |
Toxicity to microorganisms [NOEC] |
The inhibition of the degradation activity of activated sludge is not anticipated when DINA is introduced in appropriate low concentrations. |
The inhibition of the degradation activity of activated sludge is not anticipated when DEHA is introduced in appropriate low concentrations. |
Three studies investigating the long-term toxicity of Di(2-ethylhexyl) adipate (CAS 103-23-1, DEHA) to aquatic invertebrates are available. The key study was performed according to GLP and OECD guideline 202, part 2 using Daphnia magna as test organism (Huels 1996). Test concentrations from 0.5 to 2 mg/L were tested using Marlowet R40 as vehicle (2 mg/L). The stability of the highest test concentration (2 mg/L) was analytically examined. A geometric mean value of 0.77 mg/L was measured, which considerably exceeded the intrinsic water solubility of the substance (approx. 0.0032 mg/L). Nevertheless, no significant adverse effects on reproduction rate or survival of the parent animals were observed at any of the concentrations tested. Thus, the 21d-NOEC value is determined to be ≥ 0.77 mg/L (measured concentration) and > the solubility in water, respectively.
This result is confirmed by supporting studies: Robillard et al. (2008) conducted a long-term toxicity test with Daphnia magna at the saturation limit, which was measured to be an average exposure concentration of 4.4 μg/L (water solubility = 5.5 µg/Lmeasured using the slow stir method). The test concentration was chosen to avoid insoluble test material and physical entrapment. One hundred percent of the DEHA-treated organisms survived compared to 90% survival in both the control and solvent control. Mean neonate reproduction was 152, 137, and 148 and mean dry weight per surviving female was 0.804, 0.779, and 0.742 mg in the treatment, control and solvent control, respectively. No adverse effects were observed. Thus, the 21d-NOEC value is determined to be ≥ 4.4 µg/L (measured concentration) and > the solubility in water, respectively.
The data indicate that DEHA does not adversely affect aquatic invertebrates at long-term exposure in the range of its water solubility. Based on the mentioned structural similarities between the source and the target substance resulting in a similar efate and ecotoxicological profile this efferct value can also considered to be true for Diisononyl adipate (CAS 33703-08-1) and thus adequately covers this endpoint for the hazard assessment of DINA.
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