Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 232-191-3 | CAS number: 7789-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Calcium iodate does not exhibits acute toxicity by any of the routes.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
- Route of administration:
- oral: drinking water
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 358.667 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight.
- Executive summary:
The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.
Reference
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -7.18
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -7.18
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 358.667 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is predicted using QSAR toolbox Version 2.3
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Species:
- other: Human
- Strain:
- other: not applicable
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- other: "Discriminating Dose"
- Effect level:
- 1 300 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
- Executive summary:
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
Reference
The
prediction was based on dataset comprised from the following
descriptors: "discriminating dose"
Estimation method: Taking average value from the 5 nearest neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= 0.0436
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.0436
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 1 300 mg/kg bw
- Quality of whole database:
- The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.
Additional information
Acute toxicity: oral
Based on the various studies available with Klimish rating 2and 4 for the target substance Calcium iodate and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Species |
Route |
Remarks |
1 |
LD50 |
358.6667 mg/kg
|
mouse |
Oral |
Predicted data of target chemical |
2 |
LD50 |
1177 mg/kg 815 mg/kg 531 mg/kg |
mice |
Oral intraesophageal |
Data of publication for CAS NO 7758-05-6 |
3 |
LD50 |
505 mg/kg |
mice |
Oral intraesophageal |
Data of publication for CAS NO 7681-55-2 |
4 |
LD |
700 mg/kg |
Rabbit |
Oral |
Data of publication for CAS NO 7681-11-0 |
5 |
LD50 |
200-250 mg/kg |
Dog |
Oral capsule |
Data of publication for CAS NO 7758-05-6 |
6 |
other toxicity |
260 mg/kg |
Human |
Oral |
Data of publication for CAS NO 7681-11-0 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LD50 value was found to be in the range of 200 to 1177 mg/kg.Also there is evidence of toxicity effect to Human of calcium iodate. Thus according to CLP criteria it is concluded that the substance Calcium iodate exhibits acute toxicity in the Category 4.
Acute toxicity: inhalation
This end point was considered for waiver since calcium iodate has negligible vapour pressure and therefore exposure via the inhalation route is will not take place, justifying this end point for waiver.
Acute toxicity: dermal
The acute dermal toxicity values for the target substance are not available. The acute dermal median lethal dose (LD50) value of read across substance is considered for this endpoint. The discriminating dose value of potassium iodate in human were considered for this end point.
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.
Justification for selection of acute toxicity – inhalation endpoint
This end point was considered for waiver since calcium iodate has negligible vapour pressure and therefore exposure via the inhalation route is will not take place, justifying this end point for waiver.
Justification for selection of acute toxicity – dermal endpoint
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.
Justification for classification or non-classification
According to new CLP regulation classification criteria and based on the values of acute toxicity via oral, inhalative and dermal route it is concluded that the substance calcium iodate is classified as acutely toxic by oral, inhalation or dermal route in Toxic category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.