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EC number: 221-877-8 | CAS number: 3266-23-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Justification for classification or non-classification
No data/information are available for this endpoint.
Ethylene oxide (CAS: 75-21-8) was tested for effects on reproduction in rats (one-generation study). Male and female rats were offered inhalation/vapour concentrations of 10, 33 or 100 ppm for 6 hours per day and 5 days per week. No treatment-related effects were noted in either the dams exposed to 33 or 10 ppm of ethylene oxideor in their litters. Consequently, exposure of rats to 33 ppm of ethylene oxide is considered to be a non-ill effect exposure level for one generation of reproduction.
NIOSH (1981) reported about the teratologic assessment of butylene oxide, styrene oxide and methyl bromide. Rats were offered via inhalation (vapour) concentrations of 250 and 1000 ppm of 1,2-epoxybutane (CAS: 106-88-7) for 7 hours per day and 5 days per week on days 1 - 19 of gestation. There was little indication of maternal toxicity of 1,2-epoxybutane in the rat other than relatively trivial effects on weight gain and a few organ weights. Rabbits were offered 1,2-epoxybutane inhalation (vapour) concentrations of 250 and 1000 ppm for 7 hours per day and 5 days per week from day 1 - 24 of gestation. A few detectable embryotoxic effects of 1,2-epoxybutane occurred in the rabbit at the concentration which was maternally lethal.
The study with ethylene oxide does not indicate a selective reproductive toxicity though the genotoxic potential of ethylene oxide in the gonades is clearly established. It is therefore assumed that also 2,3-epoxybutane is devoid of selective reproductive effects. Moreover, the potential carcinogenicity of the material precludes a designed exposure to levels that might become relevant in terms of reproductive effects.
No classification proposal for 2,3-epoxybutane can be made.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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