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EC number: 222-376-7 | CAS number: 3452-97-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study (see also: SIDS documents in section 13; Iuclid reference [27]; Reliability assigned: 1)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
- Reference Type:
- other: summary of toxicity studies
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 3,5,5-trimethylhexan-1-ol
- EC Number:
- 222-376-7
- EC Name:
- 3,5,5-trimethylhexan-1-ol
- Cas Number:
- 3452-97-9
- Molecular formula:
- C9H20O
- IUPAC Name:
- 3,5,5-trimethylhexan-1-ol
- Details on test material:
- - Analytical purity: 97.2 %
- Name of test material (as cited in study report): 3, 5, 5-trimethylhexan-1-ol
- Physical state: liquid
- Analytical purity: 97.2 %
- Source: Kyowa Yuka Ltd., Japan
- Lot/batch No.: 707173
- Stability under test conditions: confirmed
- Storage condition of test material: in the dark, air-tight containers, refrigerated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Japan Charles River Co.
- Age at study initiation: 5-6 weeks old for both sexs
- Weight at study initiation: mean 156.7 g (149-165 g) for males; mean 133.9 g (126-144 g) for females
- Fasting period before study: 17 to 18 hours
- Housing: in groups of 5 animals in metal cages
- Accimatisation: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ± 3°C
- Humidity (%): 55 ± 10 %,
- Air changes (per hr): 10 to 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 40 % test substance (w/v %)
- Amount of vehicle (if gavage): dose volume 5 mL/kg bw
- Lot/batch no. (if required):
- Purity: pharmaceutical grade (Japan Pharmacopoiea)
MAXIMUM DOSE VOLUME APPLIED:
5 mL/kg bw - Doses:
- Definitive study: 2000 mg/kg bw
Selected based on results of preliminary study: 0, 500, 1000, and 2000 mg/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations daily until day 14; animals were weighed on days 1, 3, 5, 10 and 14 after the drug was administered
- Necropsy of survivors performed: yes
- Other examinations performed: histopathology (organs examined: liver, kidneys, spleen, heart, lungs, brain (cerebrum, cerebellum), stomach (anterior stomach, glandular stomach), duodenum, jejunum, ileum, cecum, colon, rectum and ovaries, testes, epididymis) - Statistics:
- not needed
Results and discussion
- Preliminary study:
- There were no deaths in the preliminary study (i.e. LD50 was >2000 mg/kg bw); clinical sign (reduced movements) was seen after dosing, but was reversible within one day; significantly reduced body weight was seen in males throughout days 1-14, in females on days 1-3; there were no histopathological changes noted.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no death occurred
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no death occurred
- Mortality:
- No death occurred of either males or females
- Clinical signs:
- other: A decrease in spontaneous motor activity was observed; this was reversible on the day of administration.
- Gross pathology:
- No changes were detected on autopsy or histopathological examination.
- Other findings:
- - Histopathology: no changes noted
- Potential target organs: none identified
Any other information on results incl. tables
No deaths occurred of either males or females and the LD50 was estimated to be more than 2000 mg/kg bw. A reversible decrease in spontaneous motor activity was observed on the day of administration, and body weight gains were suppressed or tended to be suppressed from days 1 to 14 of administration in males and females. No changes were detected on autopsy or histopathological examination.
LD50: Male, > 2000 mg/kg bw; female, > 2000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 (oral, rat, 14 days) was >2000 mg/kg body weight. No target organ could be identified.
- Executive summary:
The acute oral LD50 (oral, rat, 14 days) of 3, 5, 5 -trimethylhexan-1-ol was >2000 mg/kg body weight in a study conducted according to OECD TG 401 and under GLP conditions using groups of 5 rats per sex and dose in a preliminary study (0, 500, 1000, 2000 mg/kg bw) and in the definitive study (2000 mg/kg bw).
No deaths occurred of either males or females. A reversible decrease in spontaneous motor activity was observed on the day of administration, and body weight gains were suppressed or tended to be suppressed from days 1 to 14 of administration in males and females. No changes were detected on autopsy or histopathological examination, i.e. a target organ could not be identified (Yoshimura et al., 2007).
The study is considered to be acceptable for assessment.
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