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EC number: 230-743-8 | CAS number: 7299-99-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusions for2,2-bis[[(2-ethyl-1-oxohexyl) oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate) (EC# 230-743-8) are based on read across from analogue substances of a known category of which the members were notified under Directive 67/548/EEC (NONS) in 2003/2004.
Based on the similar physico-chemical properties obtained for all members of the category in combination with the available experimental data for environmental endpoints, it can be expected that all substances would cause similar environmental toxicity,despite the variation of chain length and the presence of branchedvs. linear fatty acid esters. With an average molecular weight of 640, the substance of interest, i.e. 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) falls well within the average molecular weight range of the members of the category (637 – 1023).
At the slightly basic pH’s seen in aquatic systems, the hydrolysis of the pentaerythrithol esters may be limited for steric reasons, i.e. the ester groups are expected to be well shielded by the aliphatic substituents and thus not be accessible for hydrolytic degradation. Therefore it is expected that the substances will be present mainly unsplit and that the toxicity of the intact moiety needs to be considered.
The ability of the pentaerythrithol esters to reach the target sites in aquatic organisms will depend strongly on their solubility and their octanol-water partition coefficient. Solubility of the members of the category is in general low and the octanol-water partition coefficient is very high (EpiWin). Therefore, bioaccumulation in aquatic organisms is not favoured.
Based on the above considerations, it can be concluded that the eco-toxicological properties for 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)(EC# 230-743-8) can be derived directly by read-across from known esters.
Acute toxicity to fish (LL50) is > 100 mg/l, i.e. >> water solubility.
Acute toxicity to aquatic invertebrates (Daphnia) (EL50) is > 100 mg/l, i.e. >> water solubility.
Acute toxicity to aquatic plants (Algae) (EL50) is > 100 mg/l, i.e. >> water solubility.
At a concentration of 100 mg/l, i.e. >> water solubility, the substances are not toxic to waste water (activated sludge) bacteria.
As there are no effects at the limit of solubility within water, derivation of a PNEC is not applicable. All PNECS would be “greater than” values, and hence are meaningless. The substance is not hazardous to the environment.
Conclusion on classification
The 50% effect criterion up to the water solubility has not been reached in acute studies performed with analogue substances. Based on read-across it was concluded that the substance is not readily biodegradable. Based on this and a high log Kow, the substance does not need to be classified for the environment according to CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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