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EC number: 210-734-5 | CAS number: 622-40-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral: The acute oral LD50 was determined to be 5500 mg/kg bw in rats.
Dermal: The acute dermal LD50 was determined to be 16000 mg/kg bw in rabbits.
Inhalation: No mortalilty was detected when mice were exposed to a saturated atmosphere of the test substance for 8 hours.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 500 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 16 000 mg/kg bw
Additional information
Oral:
In the key study, the test article 2 -morpholinoethanol was administered by gavage to five exposure groups (4000, 6300, 8000 and 10000 mg/kg bw, determined by a prescreen) of 10 Sprague Dawley rats (5/sex) weighing 180 to 360 g after fasting. Study duration was 14 days. Oral LD 50 (males and females) was determined to be 5500 mg/kg bw, by the method of Litchfield and Wilcoxon (1949). Mortality pattern was 4/10 @ 4000 mg/kg bw; 3/10 @ 5000 mg/kg bw; 8/10 @ 6300 mg/kg bw; 9/10 @ 8000 mg/kg bw; and 10/10 @ 10000 mg/kg bw . Necropsy findings (study deaths) were diffused red and fluid-filled stomachs, distended, discolored, and congested intestines. At terminal necropsy no visible lesions were observed (Papciak, 1990).
Both supporting studies are of limited reliability, but confirming the result of the key study, that the test substance is of very acute low toxicity:
- In an acute oral toxicity study, groups of US rats (5/sex) were given a single oral dose of 2-morpholinoethanol in water at doses of 200, 1600, 3200, 6400 µL/kg bw and observed for 7 days.
Oral LD50 ca. 6400 µL/kg bw equivalent to 6784 mg/kg bw (BASF, 1968).
- In an acute oral toxicity study, groups of 10 Sherman rats were given a single oral dose of 2-morpholinoethanol in ethanol.
Oral LD50 = 12060 mg/kg bw (Smyth, 1948).
Dermal:
Four exposure groups (6300, 8000, 10000 and 16000 mg/kg bw, determined by a prescreen) of 4 New Zealand White rabbits (5/sex), weighing 2 to 3 kg, received test article 2 -morpholonoethanol on shaved, intact skin of their backs (about 10 % of total body area), for 24 hours using non-occluding dressings. Study duration was 14 days. The dermal LD 50 (males and females) was determined to be > 16000 mg/kg bw. Mortality pattern was1/10 @ 6300 mg/kg bw; 0/10 @ 8000, 10000 and 16000 mg/kg bw. Necropsy findings (study death) determined that death was not compound related. At terminal necropsy no visible lesions were observed (Papciak, 1990).
Inhalation:
In an acute inhalation toxicity study, one group of rats (6/sex) was exposed for 8 h to a saturated atmosphere of 2-morpholinoethanol at 20°C. Animals then were observed for 7 days. No mortality occurred. Eye secretion was noted (BASF 1968).
Other routes:
In an acute toxicity study, groups of Kisslegg mice (5/sex) were given a single intraperitoneal dose of 2-morpholinoethanol in water at doses of 200, 1600, 2500 and 3200 µL/kg bw and observed for 7 days.
Intraperitoneal LD50 = 2650 mg/kg bw (BASF, 1968)
Justification for classification or non-classification
Based on the test results (oral LD50 = 5500 mg/kg bw, dermal LD50 = 16000 mg/kg bw, no mortality when exposed to a saturated atmosphere for 8 hours), 2 -morpholinoethanol has not to be classified with regard to acute toxicity according to Regulation (EC) No 1272/2008 (CLP, GHS).
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