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EC number: 907-349-6
CAS number: -
Table 1: Summary of results from the bone marrow micronucleus test with
Number of mice
Micronucleated poly- chromatic number per 1000 PCEs (Mean ± S.D.)
per PCEs scored
* p ≤ 0.05 (Kastenbaum-Bowman Tables)
Male and female ICR mice were exposed to
0.5, 2.5 or 5 ml/kg of octadecyl isocyanate which was administered as a
single i.p. injection. Bone marrow cells, collected 24, 48 and 72 hours
after treatment, were examined microscopically for micronucleated
polychromatic erythrocytes. No change in the ratio of polychromatic
erythrocytes to total erythrocytes was observed in male or female mice
in the test article treated groups,suggesting that the test article did
not induce bone marrow toxicity. No significant increases in
micronucleated polychromatic erythrocytes were observed at 24, 48 or 72
hours after dose administration in males or females. The results of the
assay indicate that under the conditions described, octadecyl isocyanate
did not induce a significant increase in micronucleated polychromatic
erythrocytes in male or female ICR mice. Therefore, octadecyl isocyanate
was concluded to be negative in the mouse micronucleus assay.
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