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Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Immediately remove to fresh air. Consult a physician if

irritating symptoms develop and persist.

Emergency measure - Eyes: Rinse immediately with gently running water for 15

minutes, maintaining eyelids open. Consult an

ophthalmologist or a physician.

Emergency measure - Skin: Take off all contaminated clothing immediately. After

contact with skin, wash immediately with plenty of water and

soap.

Emergency measure - Ingestion: Provided person is conscious, wash out mouth with water.

Call a physician immediately.

Fire-fighting measures

Recommended extinguishing agent: Water spray jet, foam, dry powder & caobon dioxide

Product arising from burning: Carbon oxides, nitrogen oxides

Product determined by test: N

Protective equipment: Wear self-contained breathing apparatus and protective suit.

Accidental release measures

Emergency measures in case of spillage: Personal Ptotective Equipment for open handling is outlined

as follows:

Respiratory protection: In case of airborne dust: Air-

purifying disposable particulate mask or air-purifying

reusable face respirator.

Eye protection: safety glasses according to EN166

Hand protection: chemical resistant gloves (EN374/EN188)

Others: working clothes - Disposable Tyvek suit

The precautions to be taken in case of accidental release

are outlined as follows:

After spillage, leakage, gas leakage, small amounts:

Evacuate endangered area, avoid sparks, seal off area. Call

fire brigade immediately. Must not be released into sewers,

drains or wells. Wear heavy protective equipment (as stated

above). Take up by mechanical means and dispose. Place into

closable and properly labelled drums.

Cleaning of equipment: Wash with plenty of water in a safe

way. The substance is not, or only partly miscible with

water.

Handling and storage

Handling: The material arrives on site in Fibre Drums with plastic

inliner. A sample of material is taken for analysis on site.

This is carried out in a laminar flow booth while the

operator has additional protection using suitable

respiratory protection (Full face respirator with

particulate / carbon-Kemira Mask (EN149/EN143).

When the material is required for production it is

transferred in a fully contained system (Drum Contained

Powder Transfer System), from fibre drum to process vessel.

The system is designed to ensure the powder is fully

contained during the transfer.

Storage: The drums are stored fully contained in a clean, dry

warehouse protected from heat and light. All materials are

stored in accordance with the Novartis Warehouse Corporate

HSE Guidance Note 6.1. This specifies all the requirements

for safe storage of chemicals used at Novartis.

Packaging of the substance and or preparation: Material stored in warehouse in fibre kegs with double

liner, ca. 50kg / drum.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport code: RID/ADR:class 6.1/T2, UN-Nr. 2811, PGr II, LQ18
Transport: The fibre drums are transported on pallets on forklift, by
trained forklift drivers. The drums are clearly labelled
indicating the nature of the contents and the main hazards.
The forklift drivers are trained in emergency spillage
procedure.

SpecialProvisions

Stability and reactivity

Danger other than fire: None known.

Chemical reaction with water: No.

Dust explosion: Not known.

Dust explosion determined by test: N

Disposal considerations

Industry - Possibility of recovery/recycling: Based on operational history, liquid spillages are not

anticipated.  However, in the event of such a spillage, a

dedicated holding basin has been provided in the company's

wastewater treatment plant.  The facility has a continuously

monitored surface water protection system to retain

spillages, which occur outside the operational plant.

Industry - Possibility of neutralisation: In the process, all the substance is consumed.  All solid

waste and liquid waste streams are incinerated to ensure

complete destruction of residual hazardous components.

Industry - Possibility of destruction: controlled discharge: Not applicable.

Industry - Possibility of destruction - incineration: Incineration is used for all solid and liquid wastes.

Industry - Possibility of destruction - water purification: Not applicable.

Industry - Possibility of destruction - other: Not applicable.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable.

Public at large - Possibility of destruction: controlled discharge: Not applicable.

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.

Public at large - Possibility of destruction - others: Not applicable.