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Diss Factsheets
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EC number: 909-044-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1962
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Adopted from OECD SIDS. The original source is available and has been reviewed.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
- Reference Type:
- secondary source
- Title:
- Dimethyl phosphonate - CAS No: 868-85-9 - SIDS Initial Assessment Report.
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Ten male rats were exposed to 7100 mg/m³ dimethyl phophonate (calculate exposure concentration from air flow and net loss of material) for 6 hours.
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- other: no data
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl phosphonate
- EC Number:
- 212-783-8
- EC Name:
- Dimethyl phosphonate
- Cas Number:
- 868-85-9
- Molecular formula:
- C2H7O3P
- IUPAC Name:
- dimethyl phosphonate
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): dimethyl phosphonate
- Substance type: technical product
- Assumed purity: 100%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
-Housing: at termination of the exposure the animals were housed by species in metal cages elevated above the droppings.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: no data
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
-Animals were exposed for 6 hours to the near saturated vapours of the test materials. Each exposure was conducted in a 500-liter stainless steel inhalation chamber equipped at the inlet with one or two fritted-disc glass bubblers which contained the test material. A glass trap was placed in the line between this vapour generator and the chamber to collect any entrained liquid. The air flow through the system was 18 liters per minutes (one bubbler), or 35 liters per minute (two bubblers). Dimethyl phosphonate vapour was generated at room temperature.
No attempt was made to determine the actual chamber concentration during the exposure. The mean theoretical concentration was calculated for each material from the air flow and net loss material. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- 7100 mg/m³
- No. of animals per sex per dose:
- 10 (male rats)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days.
- Other examinations performed: mortality, toxic effects, autopsy. - Statistics:
- Not performed
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 7 100 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- no deaths
- Clinical signs:
- other: no clinical signs
- Body weight:
- No data
- Gross pathology:
- Congestion and hemorrhage in the lungs.
- Other findings:
- No further data
Any other information on results incl. tables
Based on the study results and according to DSD-DPD and CLP classification criteria, the test substance is not to be classified.
Applicant's summary and conclusion
- Executive summary:
Ten male rats were exposed to 7100 mg/m³ dimethyl phosphonate (calculated exposure concentration from air flow and net loss of material) for 6 hours. No deaths occurred. ongestion and hemorrhage in the lungs were observed in rats
Occidental Chemical Corporation (1992)
. Based on the study results and according to DSD-DPD and CLP classification criteria, the test substance is not to be classified.
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