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EC number: 700-155-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 3 January 2011 to 18 February 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed in accordance with OECD guideline and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- corn oil, peroxidised
- IUPAC Name:
- corn oil, peroxidised
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-97633 Sulzfeld
- Age at study initiation: no data
- Weight at study initiation: from 210 to 255 g
- Fasting period before study: no
- Housing: in transperent macrolone cages (type 3-180, floor area 810 sq.cm) with 2 or 3 in each cage, males and females separated.
- Diet: pelleted complete rodent diet "Altromin 1324", ad libitum
- Water: free access to bottles with domestic quality drinking water, which was acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth.
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature:22°C +/- 3°C
- Humidity: at least 30% and preferably not exceeding 70%
- Air changes: 10 times/hour
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: from 18 January 2011 (arrival of the animals) to 16 February 2011
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: 6 x 8 cm
- % coverage: no data
- Type of wrap if used: 4-layer gauze pack fixed with Micropore tape wound around the trunk
REMOVAL OF TEST SUBSTANCE
- Washing: yes (with mild soap and lukewarm water)
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied: 2000 mg/kg bw
- Concentration: undiluted - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- pilot study: 1 female
main study: 5 males and 5 females - Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
> clinical signs: 1, 3 and 6 hours after the start of the application and thereafter once daily for a period of 14 consecutive days
> body weight: on day 0, 7 and 14
- Necropsy of survivors performed: yes - Statistics:
- not applicable
Results and discussion
- Preliminary study:
- The animal included in the pilot study survived to the treatment.
The rat had a normal body weight gain during the study period.
On day 0 after 1 hr, 3 hrs and 6 hrs, the animal showed lower activity (apathy) probably caused by limited mobility resulting from the tape fixation of the patch. From day 1 to the end of the observation period on day 14 no abnormalities were revealed.
The post mortem inspection revealed no pathological abnormalities.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- act. ingr.
- Remarks on result:
- other: no mortality
- Mortality:
- Neither male nor female rats died on account of the treatment or showed severe signs of toxicity.
- Clinical signs:
- The animals showed lower activity (apathy) probably caused by limited mobility resulting from the tape fixation of the patch on day 0 after 1 hr, 3 hrs and 6 hrs. From day 1 to the end of the observation period on day 14 no abnormalities were revealed.
- Body weight:
- The rats had a normal body weight gain during the study period.
- Gross pathology:
- The post mortem inspection revealed no pathological abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of peroxidised corn oil in rats was found to be above 2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study according to OECD TG 402 and GLP (Vaeth A., 2011), groups of Wistar rats (5/sex) were dermally exposed to undiluted peroxidised corn oil for 24 hours to 6x8cm at the dose of 2000 mg/kg bw (limit test). Animals then were observed for 14 days. During the study clinical signs of reaction to the treatment were recorded daily. Body weight was recorded once a week. After the 2-week observation period, the animals were killed and subjected to gross necropsy examination.
Male/female LD50 > 2000 mg/kg bw
Neither male nor female rats died on account of the treatment or showed severe signs of toxicity.
The animals showed lower activity (apathy) probably caused by limited mobility resulting from the tape fixation of the patch on day 0 after 1 hr, 3 hrs and 6 hrs. From day 1 to the end of the observation period on day 14 no abnormalities were revealed.
The rats had a normal body weight gain during the study period.
The post mortem inspection revealed no pathological abnormalities.
No classification for acute dermal toxicity is warranted based on the absence of mortality up to a limit dose level, according to the criteria of EU GHS.
This study is classified as acceptable, as it is performed according to OECD guideline and GLP.
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