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Diss Factsheets
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EC number: 247-501-2 | CAS number: 26175-68-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- occlusive dressing
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- EC Number:
- 247-501-2
- EC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzenesulphonamide
- Cas Number:
- 26175-68-8
- Molecular formula:
- C8H10Cl2N2O2S
- IUPAC Name:
- 4-amino-2,5-dichloro-N,N-dimethylbenzene-1-sulfonamide
- Details on test material:
- - Name of test material (as cited in study report): 1-Amino-2,5-dichlorbenzol-4-sulfonsaeure-dimethylamid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoering AG, 4414 Fuellinsdorf, Switzerland
- Age at study initiation: approx. 12 weeks
- Weight at study initiation: 2.3 - 3.0 kg
- Housing: individually in stainless steel cages with automatic drinking water supply and cleaning system
- Diet: pelleted standard Kliba 341, rabbit maintenance diet ad libitum
- Water: tap water ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+-2
- Humidity (%): 55+-10
- Photoperiod : Light cycle 12 hours/day
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: Polyethyleneglycol / Saline = 7 / 3
- Controls:
- no
- Amount / concentration applied:
- The test material was applied under a patch of filter paper approx. 3 cm x 3 cm. 1 g of a 50% suspension of the test substance diluted with polyethyleneglyol/saline (7/3) was used. When the patch was in place it was covered with impermeable material and fastened to the body with adhesive tape.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 (1 male, 2 females)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: # 140, 141, 142 each
- Time point:
- other: mean of 24, 48, and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (erythema) at any time
- Irritation parameter:
- edema score
- Basis:
- animal: # 140, 141, 142 each
- Time point:
- other: mean of 24, 48, and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (edema) at any time
- Irritant / corrosive response data:
- no signs of irritation or corrosion at any time
- Other effects:
- NO ACUTE TOXICOLOGICAL SIGNS WERE OBSERVED IN THE ANIMALS DURING THE TEST PERIOD.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Not irritating and not corrosive to the skin.
- Executive summary:
When testing for acute dermal irritation/corrosion in rabbits according to OECD 404 the test substance showed no signs of irritation (all scores 0). No destructions or irreversible alterations of the treated skin were observed. Thus it was concluded that the test substance is not irritating and not corrosive to skin.
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