Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 January 2008 - 14 May 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Details on test material:
- - Name of test material (as cited in study report): S-500
- Physical state: yellow powder
- Lot/batch No.: MF1456-2345
- Expiration date of the lot/batch: 18 August 2011
- Storage condition of test material: At room temperature in the dark
- Stability under storage conditions: Stable
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- > 3 200 000
- Temp.:
- 23 °C
- pH:
- 7
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 23 °C
- pH:
- 7
- Details on results:
- In the chromatogram of the test substance solution no test substance peak was observed during isocratic elution with 75/25 (v/v) methanol/water. Under the same analytical conditions, the retention time of 2,4-DDT (log Pow = 6.5) was 26.4 minutes. Yet, three test substance peaks were observed at approximately 31.2, 34.5 and 37.9 minutes, respectively, which is during the column rinse, i.e. under gradient conditions. Hence, it was concluded that the log Pow of all UV-visible components of the test substance was > 6.5 (Pow > 3.2 x 10^6).
The results of the Rekker calculation method and the HPLC method differ more than 0.3 log units. Since the HPLC method is a more accurate method, the results of this method are reported.
Applicant's summary and conclusion
- Conclusions:
- The estimated Pow and log Pow values of the UV-active components of S-500 are > 3.2 x 10^6 and > 6.5 respectively.
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