Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 938-702-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
4-Cyclohexan-1-ol, dodecyl, branched was tested for ready biodegradation according to OECD 301B (July 1992). A suspension of the test tem in a mineral medium, corresponding to 20 mg/l TOC was inoculated with activated sludge (30 mg d.s./l) of a predominently domestic wastewater treatment plant. The test vessels were aerated by the passage of carbon dioxide-free air and were incubated under aerobic conditions in diffuse light for 28 days. Degradation was followed by determining the carbon dioxide produced and absorbed to sodium hydroxide via IC-measurement. A reference control (sodium benzoate, 20 mg DOC/l) and a toxicity control (test item and sodium benzoate in an amount of 40 mg organic carbon/l) were tested in parallel. The mean degradation extent of the test item was -7% within 28 days after acidification (mean value of three test vessels). The reference compound sodium benzoate reached the pass levels for ready biodegradability within 4 days. The degradation in the toxicity control reached 40.6% with 11 days, showing that the test item had no toxic effect to the activated sludge.
Therefore the test item 4 -Cyclohexan-1-ol, dodecyl, branched was judged to be not biodegradable according to OECD 301B. Thus the substance may be persistent in the environment.
The log Kow (Pow) for Cyclohexanol, 4-C11-12-alkyl, branched measured according to OECD guideline 117 was 7.1 at approx. 22° C and a pH of 6-7.
Three different structures of possible components of the Cyclohexanol, 4-C11-12-alkyl, branched were used for the calculation of the BCF. There were used C11 and C12-alkyl structures with different branching. The BCFBAF version 3.01 programme of the EPI Suite software (EPIWEB 4.1) was used to predict the BCF of the structures using the smiles codes. Based on a Arnot-Gobas method upper trophic the BCF were between 561.5 and 798.5. Based on the regression-based method the BCF were between 2186 and 11890 L/kg wet-weight. Because the Arnot-Gobas upper trophic model takes also into account the biotransformation rate constant of the substance by the organism it is lower but also much more realistic. Therefore it is concluded that the substance Cyclohexanol, 4-C11-12-alkyl, branched is not bioaccumulative (B) or (vB) because the BCF is below 2000.
Reliable (Klimisch 1) short-term toxicity studies for fish, algae and daphnia are available for Cyclohexanol, 4-C11-12-alkyl, branched and show that the substance is not toxic (T) for aquatic species (acute LL50 and EL50 values for daphnids, fish and algae are all > 100 mg/L).
The short-term toxicity of Cyclohexanol, 4-C11-12-alkyl, branched to fathead minnows (Pimephales promelas) was reported by Brougher et al., (2012) in an OECD 203 guideline and GLP compliant study. Fathead minnows were exposed to the test substance in nominal concentrations based on WAF loading rates for 96 hours, resulting in a 96 -hr LL50 of >100 mg/L. Brougher et al., (2012) reported an OECD 202 guideline and GLP compliant study. Daphnia were exposed to the test substance in nominal concentrations based on WAF loading rates for 48 hours, resulting in a 48-hr EL50 of >100 mg/L. The toxicity of Cyclohexanol, 4-C11-12-alkyl, branched to freshwater green alga Pseudokirchneriella subcapitata was reported by Arnie et al., (2012) in a GLP compiant OECD 201 guideline and EPA OCSPP 850.4500 study. Algae were exposed to the test substance in nominal concentrations based on WAF loading rates for 96 hours, resulting in a 72-hr ErL50 of >100 mg/L.The median lethal dose of Cyclohexanol, 4-C11-12-alkyl, branched after a single oral administration to female rats, observed over a perid of 14 days is LD50 > 2000 mg/kg. At a dose of 300 mg/kg bw/d after 2 h 3 animals showed slight piloerection. At 2000 mg/kg bw/d after 30 minutes there were no signs of toxicity, after 2 and 3 h slight piloerection was seen in all six animals, 3 animals showed slightly reduced spontaneous activity and bradykinesia after 4 h, after 5 hours the 3 animals showed moderately reduced spontaneous activity and moderate piloerection and d 2 until the end of the observation period no signs of toxicity were seen in all animals. None of the animals showed weight loss during the observation period.
Thus the (T) criterion is not fulfilled.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.