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reaction product of: saturated, monounsaturated and multiple unsaturated long-chained partly estrified alcohols of vegetable origin (Brassica napus L., Brassica rapa L., Helianthus annuus L., Glycine hispida, Gossypium hirsutum L., Cocos nucifera L., Elaeis guineensis) with O,O-diisobutyldithiophosphate and 2-ethylhexylamine and hydrogen peroxide
EC number: 428-630-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert statement
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The toxicokinetic assessment was derived from available physiochemical and toxicity data, not based on actual experimental examinations..
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Toxicokinetic assessment was performed based on physicochemical properties and available toxicity data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- -
- EC Number:
- 428-630-5
- EC Name:
- -
- Molecular formula:
- Not applicable
- IUPAC Name:
- reaction product of Z-9-octadecen-1-ol and O,O-diisobutyl hydrogen dithiophosphate
- Details on test material:
- - Name of test material (as cited in study report): Becrosan 6920
Constituent 1
Test animals
- Species:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Strain:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- Not Applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Not Applicable
- No. of animals per sex per dose / concentration:
- Not Applicable
- Control animals:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Positive control reference chemical:
- Not applicable
- Details on study design:
- Not applicable
- Details on dosing and sampling:
- Not applicable
- Statistics:
- Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
Results and discussion
- Preliminary studies:
- Not Applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Not Applicable
- Details on distribution in tissues:
- Not Applicable
Transfer into organs
- Transfer type:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
- Observation:
- not determined
- Details on excretion:
- Not Applicable
Toxicokinetic parameters
- Toxicokinetic parameters:
- other: Prediction toxicokinetic behavior based on physicochemical properties and available toxicity data.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not Applicable
Any other information on results incl. tables
Assessment of Toxicokinetics of Becrosan 6920
The assessment of the toxicokinetical behaviour of the test substance Becrosan 6920is based on the information of its chemical-physical properties andofthe results of acute and subacute toxicity studies.
Becrosan 6920is a mixture of lipophilic compounds whereby a Thio-phosphorus ester is the main constituent. After oral administration a good enteral absorption through the stomach and the intestine and a fast distribution is probably. Organophosphorus ester are quickly metabolised in dependence on their reactivity with ester splitting enzyrns accompanied by a decreased toxicity for mammals. After single oral or dermal administration of doses of 2000mg/kg body weight no acute or delayed toxicity signs were recorded in rats. This shows a relatively quickly absorption and excretion without systemic toxic effects. The repeated administration of doses up to1000 mg/kg body weight over 28 days in rats has given no evidence of cumulation, plasma protein binding or enzyrn induction.Theliver can be considered as the most important target organ in mammals. The activity of aspartate aminotransferase of serum was dose-dependent decreased corresponding with a slight decrease of liver weights. This is an expression of toxic effects. The liver is the site of metabolismus of the test substance possibly via a first pass effect with presystemic elimination. Other target organs seem to be the kidneys which relative weights were decreased in male rats. Histopathological findings have given no evidence of binding of the test substance to tissue sites. Therefore a relatively quickly elimination of test substance and/or its metabolites with urine and faeces is assumed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: predicted no bioaccumulation.
Based on the representative chemical structure and available physicochemical property and toxicity data, a prediction of toxicokinetic behavior was created, and absorption, distribution to distance organs, possible metabolism and excretion process were involved. - Executive summary:
Assessment of Toxicokinetics of Becrosan 6920
The assessment of the toxicokinetical behaviour of the test substance Becrosan 6920 is based on the information of its chemical-physical properties andofthe results of acute and subacute toxicity studies.
Becrosan 6920 is a mixture of lipophilic compounds whereby a Thio-phosphorus ester is the main constituent. After oral administration a good enteral absorption through the stomach and the intestine and a fast distribution is probably. Organophosphorus ester are quickly metabolised in dependence on their reactivity with ester splitting enzyrns accompanied by a decreased toxicity for mammals. After single oral or dermal administration of doses of 2000mg/kg body weight no acute or delayed toxicity signs were recorded in rats. This shows a relatively quickly absorption and excretion without systemic toxic effects. The repeated administration of doses up to1000 mg/kg body weight over 28 days in rats has given no evidence of cumulation, plasma protein binding or enzyrn induction.Theliver can be considered as the most important target organ in mammals. The activity of aspartate aminotransferase of serum was dose-dependent decreased corresponding with a slight decrease of liver weights. This is an expression of toxic effects. The liver is the site of metabolismus of the test substance possibly via a first pass effect with presystemic elimination. Other target organs seem to be the kidneys which relative weights were decreased in male rats. Histopathological findings have given no evidence of binding of the test substance to tissue sites. Therefore a relatively quickly elimination of test substance and/or its metabolites with urine and faeces is assumed.
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