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EC number: 800-035-9 | CAS number: 1374645-21-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 13 Dec - 16 Dec 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- adopted in 2006
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Standards Council of Canada, Ottawa, Canada
Test material
- Reference substance name:
- niobium oxygen sulfur zinc λ²-stannane
- EC Number:
- 800-035-9
- Cas Number:
- 1374645-21-2
- Molecular formula:
- Sn1.8Zn0.2Nb2O6.8S0.2 (Sn(2-x)Zn(x)Nb2O(7-y)S(y) with x/2 ≤ y, 0.02 ≤ x ≤ 0.22, 0.01 ≤ y ≤ 0.22)
- IUPAC Name:
- niobium oxygen sulfur zinc λ²-stannane
- Details on test material:
- - Name of test material (as cited in study report): EX1455, Niobium Sulfur Tin Zinc Oxide
- Physical state: Solid, yellow powder
- Analytical purity: 100%
- Lot/batch No.: L1903
- Storage condition of test material: At ambient temperature and out of direct sunlight
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: All concentrations were sampled.
- Sampling method: Duplicate 100 mL samples were collected immediately at test start (0 h) and at test termination (72 h, pooled replicates).
- Sample storage conditions before analysis: Samples were preserved using HNO3 for total metals and filtered and preserved using HNO3 for dissolved metals. Samples were refrigerated until analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Preparation of the test solutions followed OECD’s Guidance Document on Aquatic Toxicity Testing on Difficult Substances and Mixtures (OECD, 2000). A nominal concentration of 100 mg/L was selected as the maximum concentration of the test item to be tested for all range finding and definitive tests.
For the range-finding test, a 1 L solution of a 100 mg/L nominal concentration was prepared by adding 50.04 mg of EX1455 into 500 mL of filter-sterilised algal nutrient medium in an appropriate container and stirring for 1 h at room temperature. This solution was settled for approx. 2 h. At this time visible solids were still present in solution, in contrast the results of a preliminary test with Daphnia magna, where the solid material had settled within 3 h. Despite the presence of solid material in solution, preparation of the remaining test solutions was completed at this time. A total of 500 mL of the 100 mg/L test solution was decanted for testing leaving the settled solids behind. All lower concentrations of the test item were prepared by serial dilution.
For the definitive test (limit-test), a single exposure concentration of 100 mg/L was prepared by adding 100.05 mg of the test item into 1 L of filter sterilized nutrient medium in an appropriate container and stirring for 1 h at room temperature. This solution was settled for 48 h.
Test organisms
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Source (laboratory, culture collection): Laboratory culture since 1999; originally obtained from the University of Texas (UTEX 1648).
- Method of cultivation: Cultures are aseptically transferred twice weekly (typically from 3 – 7 day old donors) and maintained in temperature and light controlled environments isolated from all testing. The axenic nature of the stock culture is verified by plating on Trypticase Soy Agar (TSA) and Plate Count Agar (PCA).
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 22 °C constant temperature
- pH:
- 7.3 - 7.5
- Nominal and measured concentrations:
- Nominal: 0 and 100 mg/L
Measured (dissolved after 72 h) for nominal 0 mg/L: < LOD (tin, zinc, niobium) and 1.078 – 1.463 mg/L (sulfur)
Measured (dissolved after 72 h) for nominal 100 mg/L: < LOD (tin and niobium), 0.007 - 0.010 mg/L (zinc) and 1.231 – 1.737 mg/L (sulfur)
Measured (total after 72 h) for nominal 100 mg/L: < LOD (tin and niobium), 0.009 - 0.011 mg/L (zinc) and 1.347 – 1.490 mg/L (sulfur) - Details on test conditions:
- TEST SYSTEM
- Test vessel: Erlenmeyer flasks
- Type (delete if not applicable): closed
- Material, size, fill volume: Glass, 250 mL, 50 mL
- Shaking: Continuous shaking on a rotary shaker at 100 rpm
- Initial cells density: 8275 cells/mL
- Control end cells density:2.4E06 cells/mL
- No. of vessels per concentration (replicates): 6
- No. of vessels per control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes; Environment Canada (2007) medium which meets the nutrient requirements of the OECD guideline.
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Nanopure II water free of particles, ions, organic molecules and microorganisms greater than 0.45 µm. Nutrient medium is filter sterilised prior to use in cultures and in testing.
- Total organic carbon: < 2 mg/L
- Intervals of water quality measurement: pH values are measured at test start and test end.
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: No
- Photoperiod: Continuous illumination
- Light intensity and quality: 6406 - 6707 lux, cool-white fluorescent
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: At 0, 24, 48 and 72 h using a haemocytometer
- Other: Observation of changes in cell development or appearance
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Range finding study
- Test concentrations: 0, 0.001, 0.01, 0.1, 1.0, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study: No effects in the range of water solubility were observed. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- growth rate
- Remarks on result:
- other: Test item solution was stirred for 2 h and then allowed to settle for 48 h; decanted solution was used for testing.
- Duration:
- 72 h
- Dose descriptor:
- EL50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- WAF
- Basis for effect:
- other: yield
- Remarks on result:
- other: Test item solution was stirred for 2 h and then allowed to settle for 48 h; decanted solution was used for testing.
- Details on results:
- - Exponential growth in the control (for algal test): yes, multiplication factor of 290
- Effect concentrations exceeding solubility of substance in test medium: Yes - Reported statistics and error estimates:
- Calculations of effect concentrations were conducted using the Equal Variance Two-Sample Test (CETIS, 2007).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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