Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-239-8 | CAS number: 68526-91-0 A complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isotridecanal from the hydroformylation of dodecene. It consists predominantly of C13-14 primary aliphatic alcohols, C22-28 dimer alcohols, C26 acetals and esters, and C>10 acid sodium salts and boils in the range of approximately 250°C to 450°C (482°F to 842°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (no washing out of the test substance)
- GLP compliance:
- no
Test material
- Reference substance name:
- Dodecene, hydroformylation products, high-boiling
- EC Number:
- 271-239-8
- EC Name:
- Dodecene, hydroformylation products, high-boiling
- Cas Number:
- 68526-91-0
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction products of dodecene, hydroformylation products, high boiling
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 13
- Physical state: liquid, clear
- Composition of test material: mixture of C13-alcohols, C13-acids and -esters
- Stability under test conditions: yes
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Age at study initiation: no data
- Weight at study initiation: mean males: 2.52 kg; female: 2.47 kg
- Housing: single
- Diet: about 130 g per animal and day (Ovator Solikanin 4 mm)
- Water: about 250 ml per animal and day
- Acclimation period: about 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-26
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of same animal
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 ml
- Duration of treatment / exposure:
- 8 days (no washing out of the test substance)
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 3 (one female, two males)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: no washing conducted
SCORING SYSTEM: as described in OECD guideline 405/Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24-72 hrs
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24-72 hrs
- Score:
- 1.7
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24-72 hrs
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24-72 hrs
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24-72 hrs
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24-72 hrs
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hrs
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24-72 hrs
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- discharge: slightly (two animals)/clearly (one male animal) increased 24 hrs after application, reversible within 48 hrs after application
- Other effects:
- female: constricted pupil 24 hrs after application, reversible within 48 hrs after application
Any other information on results incl. tables
Cornea | Iris | Conjunctiva | ||||||
Animal | Reading | Opacity | Area involved | Redness | Chemosis | Discharge | Comment | |
1 | 24 hrs | 0 | 0 | 0 | 2 | 1 | 1 | PC |
2 | 24 hrs | 0 | 0 | 0 | 2 | 1 | 2 | |
3 | 24 hrs | 0 | 0 | 0 | 2 | 1 | 1 | |
1 | 48 hrs | 0 | 0 | 0 | 2 | 1 | 0 | |
2 | 48 hrs | 0 | 0 | 0 | 2 | 0 | 0 | |
3 | 48 hrs | 0 | 0 | 0 | 2 | 1 | 0 | |
1 | 72 hrs | 0 | 0 | 0 | 1 | 1 | 0 | |
2 | 72 hrs | 0 | 0 | 0 | 2 | 0 | 0 | |
3 | 72 hrs | 0 | 0 | 0 | 2 | 1 | 0 | |
1 | 8 d | 0 | 0 | 0 | 0 | 0 | 0 | |
2 | 8 d | 0 | 0 | 0 | 0 | 0 | 0 | |
3 | 8 d | 0 | 0 | 0 | 0 | 0 | 0 | |
mean animal 1-3 | 24/48/72 hrs | 0.0 | 0.0 | 1.9 | 0.8 | 0.4 | ||
PC pupil contracted |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Due to the redness of the conjunctiva in two of three animals the test substance is classified as irritating to the eyes category 2 according to GHS-EU and category 2B according to GHS-UN.
According to 67/548/EEC, the substance is classified not eye irritating. - Executive summary:
The study is conducted according to OECD Guideline 405 and is reliable (deviation: no washing out of the test substance).
Due to the redness of the conjunctiva in two of three animals the test substance is classified as irritating to the eyes category 2 according to GHS-EU and category 2B according to GHS-UN.
According to 67/548/EEC, the substance is classified not eye irritating.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.