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Diss Factsheets
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EC number: 411-700-4 | CAS number: 140921-24-0 HÄRTER VERSUCHSPRODUKT LS 2959E; HÄRTER VP LS 2959E
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The data are available from ECHA as data older than 12 years of age and no longer protected. The registrant has been unable to varify the quality of the original data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
- EC Number:
- 411-700-4
- EC Name:
- 1,6-hexanediyl-bis(2-(2-(1-ethylpentyl)-3-oxazolidinyl)ethyl)carbamate
- Cas Number:
- 140921-24-0
- Molecular formula:
- C32H62N4O6
- IUPAC Name:
- 2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- Unwashed
- Observation period (in vivo):
- 24, 48 and 72h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Any other information on results incl. tables
Irritation parameter |
Basis |
Time point |
Score |
Max.score |
Reversibility |
Remarks |
conjunctivae score (redness) |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
conjunctivae score (redness) |
animal #2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
conjunctivae score (redness) |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
conjunctivae score (redness) |
|
|
|
0 |
|
Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals) |
chemosis score |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
chemosis score |
animal #2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
chemosis score |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
chemosis score |
|
|
|
0 |
|
Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals) |
cornea score |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
cornea score |
animal #2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
cornea score |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
cornea score |
|
|
|
0 |
|
Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals) |
iris score |
animal #1 (mean score 1) |
overall at 24, 48 and 72 h |
0 |
|
|
|
iris score |
animal#2 (mean score 2) |
overall at 24, 48 and 72 h |
0 |
|
|
|
iris score |
animal #3 (mean score 3) |
overall at 24, 48 and 72 h |
0 |
|
|
|
iris score |
|
|
|
0 |
|
Max. duration: 0 h; Max. value at end of observation period: 0 (related to all animals) |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not irritating to eyes.
- Executive summary:
The test substance has been assessed for irritation to the eyes of New Zealand White rabbits by exposure unchanged. No adverse reactions have occured and the substance is considered to be not irritating to eyes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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