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Diss Factsheets
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EC number: 700-536-1 | CAS number: 25628-08-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAM Test Method Evaluation Report: Appendix G: ICCVAM Recommended Protocol for Future Studies Using the Hen's Egg Test-Chorionallantoic Membrane (HET-CAM) Test method, November 2006
- Principles of method if other than guideline:
- The hen's egg test was modified as an alternative to the rabbit's eye irritation/corrosion test. The extra-embryonal blood vessel system of the incubated chicken egg is used to observe the acute toxicological effects of irritant/corrosive test substances. This test was performed by using the chorionallantoic membrane (HET-CAM, 8d incubation) of chicken eggs
- GLP compliance:
- yes
Test material
- Reference substance name:
- 25628-80-4
- IUPAC Name:
- 25628-80-4
- Reference substance name:
- tetraethylazanium nonafluorobutane-1-sulfonate
- EC Number:
- 700-536-1
- Cas Number:
- 25628-08-4
- Molecular formula:
- C12H20F9NO3S
- IUPAC Name:
- tetraethylazanium nonafluorobutane-1-sulfonate
- Reference substance name:
- N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
- IUPAC Name:
- N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate
- Details on test material:
- content: 97.7%
Constituent 1
Constituent 2
Constituent 3
Test animals / tissue source
- Species:
- other: not applicable (in vitro study)
- Strain:
- other: not applicable (in vitro study)
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: not applicable (in vitro study)
- Duration of treatment / exposure:
- single treatment
- Observation period (in vivo):
- Effects are measured by the onset of haemorrhage, vessel lysis or coagulation during the first 300 seconds after application
- Number of animals or in vitro replicates:
- not applicable - in vitro test (4 eggs were used)
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation score (IS)
- Basis:
- mean
- Time point:
- other: 300 sec
- Score:
- 4
- Max. score:
- 37
- Reversibility:
- other: not applicable - in-vitro test
- Other effects:
- no data
Any other information on results incl. tables
HET-CAM Index
Negative Control NaCl 0.9% 0 Non irritant
Positive Control SDS 1% 11 Strong irritant
Perfluorbutansulfonsäure-
Tetraethylammonium-Salz 4 Slight irritant
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
Hen' s egg tests are used to determine the potential irritantlcorrosive property of the test compound using an in vitra alternative to the Draize methodology (OECD405).
Tetraethylammonium perfluorobutanesulfonate was tested by observing possible adverse changes after application onto the chorionallantoic membrane (HET-CAM).
After the application of the test item blood vessels and albumen were examined and scored for the following irritant effects: vasodilation, slight haemorrhage; vessel lysis, strong haemorrhage; blood coagulation, albumen coagulation for a period of 300
seconds. 300 µg of the test item was applied per egg directly on the chorionallantoic membrane.
Tetraethylammonium perfluorobutanesulfonate was identified as "slight irritant" to the chorionallantoic membrane (Irritation Score (IS) = 4) under the conditions of this assay.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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