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EC number: 692-721-8 | CAS number: 757251-39-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- May to June 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
- EC Number:
- 692-721-8
- Cas Number:
- 757251-39-1
- Molecular formula:
- C13 H12 F N3 O2
- IUPAC Name:
- 4-(4-amino-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- - Application volume: 10 mL/kg bw
- Rationale for the selection of the starting dose:
As described in the flow charts of Annex 2, OECD guideline 423, the starting dose level should be that which is most likely to produce mortality in
some of the dosed animals. Therefore, the limit dose 2000 mg/kg bw was chosen as starting dose. - Doses:
- 2000 mg/kg bw (1st step) and 300 mg/kg bw (2nd step)
- No. of animals per sex per dose:
- 3 females (2000 mg/kg bw) and 6 females (300 mg/kg bw)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: at least once daily (clinical signs, mortality) or once weekly (weight gain)
- Necropsy of survivors performed: yes - Statistics:
- none
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- other: LD50 cut-off
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: acc. to OECD Guideline 423
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 300 - 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: acc. to GHS
- Mortality:
- At the dose 2000 mg/kg bw all 3 females died within 4 hours after treatment. The dose 300 mg/kg bw was tolerated by all 6 females without mortalities.
- Clinical signs:
- other: At 2000 mg/kg bw piloerection, uncoordinated and creeping gait as well as lateral position were observed 2 to 4 hours after treatment in all animals. The dose 300 mg/kg bw showed increased motility in all animals up to 24 hours after administration.
- Gross pathology:
- No gross pathological findings were observed in animals that died during the observation period and at the end of the study.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
The acute oral toxicity of AFP-Picolinmethylamid was harmful with a LD50 of 500 mg/kg bw in rats (cut-off value) according to OECD TG 423.
According to EC Regulation 1272/2008 the LD50 of the test item is > 300 - 2000 mg/kg bw (Category 4 of the Globally Harmonized Classification System). At the limit-dose 2000 mg/kg bw all animals died within 4 hours after treatment. The dose 300 mg/kg bw was tolerated by all 6 females without mortalities. At 2000 mg/kg bw piloerection, uncoordinated gait, creeping gait and lateral position were observed 2 to 4 hours after treatment. The dose 300 mg/kg bw revealed increased motility up to 24 hours after administration. Neither effects on body weight gain nor gross pathological findings were observed.
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