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EC number: 617-903-6 | CAS number: 86675-46-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance showed moderate acute oral toxicity in male rats with a LD50 of 917 mg/kg bw. In a range finding inhalation study, the LC50 was determined at >4900 mg/m3 for male and female rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 917 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 4 900 mg/m³ air
Additional information
Oral route
In a GLP compliant acute oral toxicity study, performed according to a protocol similar to the OECD guideline 401, male Wistar rats (5/dose) were exposed to 250, 500, 1000, and 2000 mg/kg bw of Polyol IXOL M125 (Dunphar B.V. 1986). At 250 mg/kg bw no mortalities were observed; at 500 mg/kg bw, 1 animal died; at 1000 mg/kg bw: 3 animals died and 2000 mg/kg bw: 4 animals died. In survivors, in the first days after dosing there was a weight loss in all dose groups, except the 250 mg/kg bw group. Thereafter there was a recovery. Clinical signs were mainly indicative of effects on the autonomic nervous system (ptosis, diminished respiratory rate, respiratory difficulties, piloerection and hypothermia), on the central nervous system (apathy and positional passivity), on motor coordination (abnormal gait, abnormal body posture, diminished locomotor activity, loss of righting-reflex) and on muscle tone (decreased abdominal and limb tone and paralysis). Autopsy of rats that died as a result of treatment, revealed effects on the gastro-intestinal tract (irritation), kidneys (pale), liver (pale), lungs (red spots) and thymus (red spots). In the surviving animals no abnormalities were detected. The LD50 was determined to be 917 mg/kg bw.
Inhalation route
In a GLP compliant range finding inhalation toxicity study, the acute inhalation toxicity of Polyol IXOL M125 was investigated (TNO Triskelion BV 2012). In this study, groups of 3 rats per sex were exposed to 0, 0.5, 1.7 or 4.9 g/m3 Polyol IXOL M125 for 6 hours per day, 5 days per week, over a 7-day period. Clinical signs consisted of increased kidney weights in females ofthe mid and high concentration, increased liver weights in females of all exposed groups, and increased relative liver weights in males of the mid and high concentration group. Histopathological examination of the upper airways revealed treatment-related changes in the larynx at all concentration levels. Microscopic changes in the nasal tissues were limited to animals of the high concentration and one animal of the mid concentration group. At necropsy, no treatment-related macroscopic abnormalities were observed. Mortality did not occur throughout the study. It is therefore concluded that the LC50 is above 4.9 g/m3 for male and female rats.
Dermal route
In accordance with column 2 of REACH Annex VIII and IX, as acute toxicity studies for the oral and inhalation route are available, no study regarding the dermal route is needed.
Justification for classification or non-classification
As no mortality was observed after 5 days of inhalation exposure (LC50 > 4900 mg/m3, the highest dose tested), classification for acute inhalation toxicity is not needed.
The substance has to be classified for Acute toxicity, Cat. 4 via the oral route (H302, harmful if swallowed) according to the EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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