Registration Dossier
Registration Dossier
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EC number: 206-337-1 | CAS number: 328-84-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,4-dichloro-α,α,α-trifluorotoluene
- EC Number:
- 206-337-1
- EC Name:
- 3,4-dichloro-α,α,α-trifluorotoluene
- Cas Number:
- 328-84-7
- Molecular formula:
- C7H3Cl2F3
- IUPAC Name:
- 1,2-dichloro-4-(trifluoromethyl)benzene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- single application
- Doses:
- 2000 mh/kg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no deaths occurred.
- Clinical signs:
- One female was observed with scales on the back from dy 8 to day 10. No clinical signs of systemic toxicity were observed during the observation period.
- Body weight:
- Within the range of physiological variability known for rats of this strain and age.
- Gross pathology:
- No macroscopic organ findings wre noted at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of 3,4-dichloro benzotrifluoride after single dermal administration to rats of both sexes, observed over a period of 14 days, could not be estimated as no death occurred.
LD50 > 2000 mg/kg
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