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Diss Factsheets
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EC number: 903-161-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
All results are negative for genetic toxicity.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Bacterial Reverse Mutation Assay- The study was conducted in accordance with OECD guidelines 471. All criteria for a valid study were met. Under the condition of this study EC 903-161-3 did not cause a positive mutagenic response with any of the tester strains in either the presence or absence of Aroclor-induced rat liver S9. The study was concluded to be negative.
Mammalian chromosome Aberration Test- The study was conducted in accordance with the OECD guidelines 473. No significant increase in structural and numerical chromosome aberrations in the test substance-treated groups relative to the respective solvent controls in both the presence and absence of the S9 metabolic activation system was observed. The percentages of aberrant cells in the test substance-treated groups were within the historical solvent control range . The results for the positive and negative controls indicate that all criteria for valid assay were met. The cytotoxicity and chromosome aberration data of the untreated control were comparable to that of the diluent for all treatment conditions. The study was concluded to be negative.
Mouse Lymphoma Assay-The study was conducted in accordance with the OECD 476 guidelines. All criteria for a valid study were met. Under the condition of this study, test article EC 903-161-3 was concluded to be Negative in the L5178Y/TK+/- Mouse Lymphoma Mutagenesis Assay.
To summarise, test substance was not found to be mutagenic in bacteria and did not induce chromosome damage in human lymphocytes or gene mutation in mouse lymphoma cells.
Short description of key information:
Negative for mutagenicity in bacterial cultures in GLP compliant
short term in vitro tests (OECD 471)
Negative for induction of structural and numerical chromosome
aberrations (OECD 473)
Negative for gene mutation in mouse lymphoma cells (OECD 476)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
All results for genotoxic potential, in prokaryotic and eukaryotic (including mammalian) species were negative. Therefore, in accordance with EC Regulation 1272/2008, no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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