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EC number: 939-180-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- January 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Performed before test guidelines and GLP principles were in place, but performed according to the published method of Ames: only two strains were used to proof earlier positive results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Procedures followed in the present study, mimic as closely as possible those described by Ames and coworkers in Mutation Research 31, 1975, 347-365. Only S. typhimurium TA1535 and TA100 have been tested, based on findings in another performed study.
- GLP compliance:
- no
- Remarks:
- before GLP came into force
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate
- EC Number:
- 939-180-9
- Molecular formula:
- Not relevant - Multiconstituent substance
- IUPAC Name:
- 2-({3-[2,2-bis({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butoxy]-3-oxopropoxy}methyl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)butyl 3-(2-methylaziridin-1-yl)propanoate; 2-ethyl-6-(2-methylaziridin-1-yl)-2-({[3-(2-methylaziridin-1-yl)propanoyl]oxy}methyl)-4-oxohexyl 3-(2-methylaziridin-1-yl)propanoate
- Details on test material:
- - Name of test material (as cited in study report): CX-100
- Substance type: polyfunctional aziridene crosslinkers
- Physical state: yellow liquid
- Lot/batch No.: Three batches were used for testing, CX-100 PCH Lot 36.942, CX-100 PCH lot 36110 and CX-100 PCI.
- Other: Received material January 30, 1980
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA100 and TA1535
- Details on mammalian cell type (if applicable):
- approx. 10E9 bacteria/ml were used
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced livers of male wistar rats
- Test concentrations with justification for top dose:
- 0, 0.06, 0.18, 0.56, 1.67, 5, 10 mg/plate (+/- S9 mix)
- Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: DMSO
Controlsopen allclose all
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- Positive controls:
- yes
- Positive control substance:
- sodium azide
- Remarks:
- 1.3 µg/plate
Migrated to IUCLID6: without S9 mix
- Negative solvent / vehicle controls:
- yes
- Remarks:
- DMSO
- Positive controls:
- yes
- Positive control substance:
- other: 2-aminoanthracene (with S9 mix)
- Remarks:
- 0.5 µg/plate
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation); test concentrations were prepared immediately before use.
DURATION
- Exposure duration: 3 days
NUMBER OF REPLICATIONS: triplicate, positive controls in duplicate
DETERMINATION OF CYTOTOXICITY
Less dense background lawn of bacterial growth.
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA100 and TA1535
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- at 10 mg/plate the substance was toxic for the bacteria
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- The positive effect, was more pronounced in the presence than in the absence of the liver microsome activation system.
COMPARISON WITH HISTORICAL CONTROL DATA: historical positive control data are included in the report for 2-aminoanthracene (not for sodium azide)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
positive with and without metabolic activation
CX-100 showed to be positive in two strains, TA100 and TA1535, in an Ames test with and without metabolic activation.
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